Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 17, 2004
Room T-473 HSC


Speaker: Frank Yu
Topic: Acidotoxicity: Ca Entry Through ASIC1a and Neuronal Damage Following Ischemic Stroke

References:

  1. Vukicevic M, Kellenberger S. Modulatory Effects of Acid-sensing Ion Channels on Action Potential Generation in Hippocampal Neurons. Am J Physiol Cell Physiol. 2004 Sep; 287(3): C682-90.

  2. Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in Ischemia: Blocking Calcium-permeable Acid-sensing Ion Channels. Cell. 2004 Sep 17; 118(6): 687-98.

  3. Yermolaieva O, Leonard AS, Schnizler MK, Abboud FM, Welsh MJ. Extracellular Acidosis Increases Neuronal Cell Calcium by Activating Acid-sensing Ion Channel 1a. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17): 6752-7.

Reviews:

  1. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of Ischaemic Stroke: An Integrated View. Trends Neurosci. 1999 Sep; 22:391-7.

  2. Huang Y, McNamara JO. Ischemic Stroke: "Acidotoxicity" is a Perpetrator. Cell. 2004 Sep 17; 118(6): 665-6.

  3. Krishtal O. The ASICs: Signaling Molecules? Modulators? Trends Neurosci. 2003 Sept; 26(9): 477-82.

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