Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 12, 2005
Room T-473 HSC


Speaker: Travis Biechele
Topic: Help! I'm stuck! Throw me a ligand!: Therapies for Diseases of Protein Misfolding

References:

  1. Morello JP, Salahpour A, Laperriere A, Bernier V, Arthus MF, Lonergan M, Petaja-Repo U, Angers S, Morin D, Bichet DG, Bouvier M. Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. J Clin Invest. 2000 Apr; 105(7): 887-95.

  2. Bernier V, Lagace M, Lonergan M, Arthus MF, Bichet DG, Bouvier M. Functional rescue of the constitutively internalized V2 Vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059. Mol Endocrinol. 2004 Aug; 18(8): 2074-84. Epub 2004 May 27.

  3. Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004 Oct 14; 431(7010): 805-10.

Reviews:
  1. Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM. Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic. 2004 Nov; 5(11): 821-37.

  2. Ross CA, Poirier MA. Protein aggregation and neurodegenerative disease. Nat Med. 2004 Jul; 10 Suppl: S10-7. Review.


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