Pharmacology 514:
Current Topics in Pharmacology
Journal Club

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 26, 2005
Room T-473 HSC


Speaker: Ning Zheng
Topic: Exit Here If You Don't Make It: Protein Retro-Translocation Across the ER Membrane

References:

1. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 2004 Jun 24; 429(6994): 841-7.

2. Lilley BN, Ploegh HL. A membrane protein required for dislocation of misfolded proteins from the ER. Nature. 2004 Jun 24; 429(6994): 834-40.

3. Jarosch E, Taxis C, Volkwein C, Bordallo J, Finley D, Wolf DH, Sommer T. Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol. 2002 Feb; 4(2): 134-9.

4. Ye Y, Meyer HH, Rapoport TA. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature. 2001 Dec 6; 414(6864): 652-6.

5. Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 1996 Dec 5; 384(6608): 432-8.

6. Knop M, Finger A, Braun T, Hellmuth K, Wolf DH. Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J. 1996 Feb 15; 15(4): 753-63.

1. Tsai B, Ye Y, Rapoport TA. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol. 2002 Apr; 3(4): 246-55.

2. Hirsch C, Jarosch E, Sommer T, Wolf DH. Endoplasmic reticulum-associated protein degradation-one model fits all? Biochim Biophys Acta. 2004 Nov 29; 1695(1-3): 215-23.

3. Matlack KE, Mothes W, Rapoport TA. Protein translocation: tunnel vision. Cell. 1998 Feb 6; 92(3): 381-90.

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