Pharmacology 514:
Current Topics in Pharmacology
Journal Club
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, October 19, 2005
Room T-473 HSC
Speaker: Christine Cheah
Topic: Transchromosomic mice as a new model for Down Syndrome
References:
O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, Nizetic D, Tybulewicz VL, Fisher EM. An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes. Science. 2005 Sep 23;309(5743):2033-7.
Hernandez D, Mee PJ, Martin JE, Tybulewicz VLJ, Fisher EMC. Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21. Hum Mol Genet. 1999;8(5):923-33.
Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet. 2004 Oct; 5(10):725-38.
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