Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 18, 2006
Room T-473 HSC


Speaker: Trongha Phan
Topic: Double Whammy Neurofibromatosis: The Cause of Tumor Formations and Learning Disabilities

References:

  1. Zhu Y, Romero MI, Ghosh P, Ye Z, Charnay P, Rushing EJ, Marth JD, Parada LF. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76.

  2. Zhu Y, Ghosh P, Charnay P, Burns DK, Parada LF. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science. 2002 May 3;296(5569):920-2.

  3. Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature. 2002 Jan 31;415(6871):526-30. Epub 2002 Jan 16.

  4. Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ.The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005 Nov 8;15(21):1961-7.

Suggested Readings:
  1. North K. Neurofibromatosis type 1. Am J Med Genet. 2000 Summer;97(2):119-27. Review.

  2. Rubin JB, Gutmann DH. Neurofibromatosis type 1 - a model for nervous system tumour formation? Nat Rev Cancer. 2005 Jul;5(7):557-64.

  3. Weeber EJ, Sweatt JD. Molecular neurobiology of human cognition. Neuron. 2002 Mar 14;33(6):845-8. Review.


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