Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 4, 2006
Room T-473 HSC


Speaker: William Catterall
Topic: Why Warm Food Tastes Better: Thermal Gating of TRPM5 Channels in Taste Reception

References:

  1. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature. 2004 Aug 12;430(7001):748-54.

  2. Perez CA, Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, Max M, Margolskee RF. A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci. 2002 Nov;5(11):1169-76.

  3. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003 Feb 7;112(3):293-301.

  4. Liu D, Liman ER. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15160-5. Epub 2003 Dec 1.

  5. Cruz A, Green BG. Thermal stimulation of taste. Nature. 2000 Feb 24;403(6772):889-92.

  6. Talavera K, Yasumatsu K, Voets T, Droogmans G, Shigemura N, Ninomiya Y, Margolskee RF, Nilius B. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature. 2005 Dec 15;438(7070):1022-5.

Reviews:

  1. Clapham DE. TRP channels as cellular sensors. Nature. 2003 Dec 4;426(6966):517-24. Review.

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