Pharmacology 514:
Current Topics in Pharmacology
Journal Club


Announcements

Schedule

Faculty

Instructions for
Speakers


JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 10, 2006
Room T-473 HSC


Speaker: Neil Nathanson
Topic: Teaching Old DAGs New Tricks: Diacylglycerol isn't just for PKC anymore.

References:

  1. Brown M, Jacobs T, Eickholt B, Ferrari G, Teo M, Monfries C, Qi RZ, Leung T, Lim L, Hall C. Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. J Neurosci. 2004 Oct 13;24(41):8994-9004.

  2. Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. J Biol Chem. 2005 Jul 1;280(26) 24363-70.

  3. Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P. The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1924-9.

  4. Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol Cell Biol. 2006 Feb;26(3):831-42.

  5. Siliceo M, Garcia-Bernal D, Carrasco S, Diaz-Flores E, Leskow FC, Teixido J, Kazanietz MG, Merida I. Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells. J Cell Sci. 2006 Jan 1;119(Pt 1):141-52.

  6. Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006 Apr 20; [Epub ahead of print]

Reviews:
  1. Hall C, Lim L, Leung T. C1, see them all. Trends Biochem Sci. 2005 Apr;30(4):169-71.

  2. Brose N, Betz A, Wegmeyer H. Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. Curr Opin Neurobiol. 2004 Jun;14(3):328-40.


2005-2006 Journal Club Schedule
Other
Pharmacology
Courses

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives