Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 15, 2006
Room T-473 HSC


Speaker: Paul DeCaen
Topic: "Lunch with parasites: P. falciparum, P. vivax, P. ovale and P. decaen" or "Targeting the apicoplast: an opportunity for rational drug design and novel pharmaceutics for malarial treatment."

References:

  1. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31.

  2. Fichera ME, Roos DS. A plastid organelle as a drug target in apicomplexan parasites. Nature. 1997 Nov 27;390(6658):407-9.

  3. Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Turbachova I, Eberl M, Zeidler J, Lichtenthaler HK, Soldati D, Beck E. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6.

  4. Waller RF, Ralph SA, Reed MB, Su V, Douglas JD, Minnikin DE, Cowman AF, Besra GS, McFadden GI. A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrob Agents Chemother. 2003 Jan;47(1):297-301.

Reviews:
  1. McFadden GI, Roos DS. Apicomplexan plastids as drug targets. Trends Microbiol. 1999 Aug;7(8):328-33. Click here to read

  2. Vaishnava S, Striepen B. The cell biology of secondary endosymbiosis--how parasites build, divide and segregate the apicoplast. Mol Microbiol. 2006 Sep;61(6):1380-7.


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