Current Topics in Pharmacology
12:30 PM, Wednesday, November 8, 2006
Room T-473 HSC
Speaker: Nephi Stella
Topic: "'Please do not switch it off'": transcription and Huntington's disease
Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell. 2006 Oct 6;127(1):59-69.
Glass M, van Dellen A, Blakemore C, Hannan AJ, Faull RL. Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors. Neuroscience. 2004;123(1):207-12.
McCaw EA, Hu H, Gomez GT, Hebb AL, Kelly ME, Denovan-Wright EM. Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice. Eur J Biochem. 2004 Dec;271(23-24):4909-20.
Rego AC, de Almeida LP. Molecular targets and therapeutic strategies in Huntington's disease. Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):361-81.
2006-2007 Journal Club Schedule