Pharmacology 514:
Current Topics in Pharmacology
Journal Club


Announcements

Schedule

Faculty

Instructions for
Speakers


JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 10, 2007
Room T-473 HSC


Speaker: Bill Catterall
Topic: SOCs, SCID, CRAC, STIM, and Orai Revealed: The Molecular Mechanism of Store-Operated Calcium Entry

References:

  1. STIM 1:

    Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O,Kozak JA, Wagner SL, Cahalan MD, Velicelebi G, Stauderman KA. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005 169:435-45.

    Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 2005 437:902-5.

  2. Icrac and Orai in SCID:

    Feske S, Prakriya M, Rao A, Lewis RS. A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med. 2005 202:651-62.

    Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 441:179-85.

  3. Orai in Drosophila:

    Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP. CRACM1 is a plasma membrane protein essential for store-operated calcium entry. Science. 2006 312:1220-1223.

    Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A. 2006 103:9357-62.

    Soboloff J, Spassova MA, Tang XD, Hewavitharana T, Xu W, Gill DL. Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem. 2006 281:20661-5.

    Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 443:230-3.

    Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature. 2006 443:226-9.

  4. Mechanism of STIM1/Orai Regulation of Calcium Entry:

    Luik RM, Wu MM, Buchanan J, Lewis RS. The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J Cell Biol. 2006 174:815-25.

    Prakriya M, Lewis RS. Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode. J Gen Physiol. 2006 128:373-86.

    Wu MM, Buchanan J, Luik RM, Lewis RS. Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J Cell Biol. 2006 174:803-13.

    Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamopri M, Numaga T, Mori Y, Iino M, Hikida M, Kurosaki T. Coupling of STIM1 to store-operated calcium entry through its constitutive and inducible movement in the endoplasmic retuculum. Proc Natl Acad Sci U S A. 2006 103:16704-16709.

Reviews:
  1. Soboloff J, Spassova MA, Dziadek MA, Gill DL. Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication. Biochim Biophys Acta. 2006 1763:1161-8.


2006-2007 Journal Club Schedule
Other
Pharmacology
Courses

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives