Pharmacology 514:
Current Topics in Pharmacology
Journal Club

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 17, 2007
Room T-473 HSC


Speaker: Steve Kraynik
Topic: Assault on GALT: The First Casualty in HIV Pathogenesis

References:

1. HIV and GALT:
   

   Guadalupe, M. et al. Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection. J. of Virology. August 2006 p.8236-8247.

   Brenchley, J.M., et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Medicine. v12. no.12. December 2006.

2. Other References:
   

   Veazey, R.S., et al. Gastrointestinal Tract as a Major Site of CD4+ T Cell Depletion and Viral Replication in SIV Infection. Science. v280. April 1998.

   Brenchley, J.M., et al. CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract. J Exp. Med. v200. no.6. September 2004.

1. Stevenson, M. HIV-1 Pathogenesis. Nature Medicine. v9. no.7 July 2003.

2. Brenchley, J.M., et al. HIV disease: fallout from a mucosal catastrophy? Nature Immunology. v7. no.3 March 2006.

3. Grossman, Z., et al. Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nature Medicine. v12. no.3. March 2006.

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