Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 7, 2007
Room T-473 HSC


Speaker: Richard Gardner
Topic: Mom always licked you better! Increased maternal nurturing in rats causes epigenetic changes in childhood that influence adult behavior.

References:

  1. Weaver IC, Cervoni N, Champagne FA, D'Alesso AC, Sharma S, Seckl JR, Dymov S, Szyf M and Meaney MJ. 2004. Epigenetic programming by maternal behavior. Nature Neuroscience 7:847-854.

  2. Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, and Szyf M. 2005. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. Journal of Neuroscience 225:11045-11054.

  3. Champagne FA, Weaver IC, Diorio J, Dymov S, Szyf M, and Meaney MJ. 2006. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology 147:2909-2915.

  4. Weaver IC, Meaney MJ, and Szyf M. 2006. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proceedings of the National Academy of Sciences 103:3480-3485.

Reviews:
  1. Repetti RL, Taylor SE, and Seeman TE. 2002. Risky families: family social environments and the mental and physical health of offspring. Psychological Bulletin 128:330-366.

  2. Luecken LJ and Lemery KS. 2004. Early caregiving and physiological stress responses. Clinical Psychology Review 24: 171-191.

  3. Fish EW, Shahrokh D, Bagot R, Caldji C, Bredy T, Szyf M, and Meaney KJ. 2004. Epigenetic Programming of Stress Responses through Variations in Maternal Care. Annals of the New York Academy of Sciences 1036:167-180.

  4. Meaney MJ and Szyf S. 2005. Maternal care as a model for experience-dependent chromatin plasticity? Trends in Neuroscience 28:456-463.


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