Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 9, 2007
Room T-473 HSC


Speaker: Neil Nathanson
Topic: Celltype- Specific Translational Control: Control Mechanisms for Him, and HER, TOO

References:

  1. Child SJ, Miller MK, Geballe AP. Cell type-dependent and -independent control of HER-2/neu translation. Int J Biochem Cell Biol. 1999 Jan;31(1):201-13.

  2. Child SJ, Miller MK, Geballe AP. Translational control by an upstream open reading frame in the HER-2/neu transcript. J Biol Chem. 1999 Aug 20;274(34):24335-41.

  3. Mehta A, Trotta CR, Peltz SW. Derepression of the Her-2 uORF is mediated by a novel post-transcriptional control mechanism in cancer cells. Genes Dev. 2006 Apr 15;20(8):939-53.

Reviews:
  1. Meijer HA, Thomas AA. Control of eukaryotic protein synthesis by upstream open reading frames in the 5'-untranslated region of an mRNA. Biochem J. 2002 Oct 1;367(Pt 1):1-11.

  2. Proud CG. Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J. 2007 Apr 15;403(2):217-34


2006-2007 Journal Club Schedule
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Pharmacology
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