Pharmacology Pharmacology

Current Topics in Pharmacology

12:30 PM, Thursday, January 10, 2008 | Room T-739 HSC
Speaker: Dr. Bill Catterall
Topic: Docked, Primed, Fast, and Synchronous: New Insights Into the Essential Molecular Players in Neurotransmitter Release
Paper to be presented:

  1. Wojcik SM, Brose N. 2007. Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter. Neuron 55:11-24.
Suggested Background Reading:
  1. Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N. 2007. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131:796-808.
  2. Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, Südhof TC. 2006. Synaptotagmin-2 is essential for survival and contributes to calcium triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci. 26:13493-13504.
  3. Xu J, Mashimo T, Südhof TC. 2007. Synaptotagmin-1, -2, and -9: Calcium sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron 54:567-581.
  4. Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC. 2007. A dual-calcium-sensor model for neurotransmitter release in a central synapse. Nature 450:676-682.
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