Pharmacology Pharmacology

Current Topics in Pharmacology

12:30 PM, Thursday, April 17, 2008 | Room T-473 HSC
Speaker: Vladimir Yarov-Yarovoy
Topic: Computational enzyme design: From a dream to reality.

  1. Rothlisberger, D., Khersonsky, O., Wollacott A.M., Jiang, L., DeChancie, J., Betker, J., Gallaher, J.L., Althoff, E.A., Zanghellini, A., Dym, O., Albeck, S., Houk, K.N., Tawfik, D.S., and Baker D. (2008) Kemp elimination catalysts by computational enzyme design. Nature (advance online publication 19 March 2008).
  2. Jiang, L., Althoff, E.A., Clemente, F.R., Doyle, L., Rothlisberger, D., Zanghellini, A., Gallaher, J.L., Betker, J.L., Tanaka, F., Barbas, C.F., 3rd, Hilvert, D., Houk, K.N., Stoddard, B.L., and Baker, D. (2008). De novo computational design of retro-aldol enzymes. Science 319, 1387-1391.
  3. Ashworth, J., Havranek, J.J., Duarte, C.M., Sussman, D., Monnat, R.J., Jr., Stoddard, B.L., and Baker, D. (2006). Computational redesign of endonuclease DNA binding and cleavage specificity. Nature 441, 656-659.
  4. Kuhlman, B., Dantas, G., Ireton, G.C., Varani, G., Stoddard, B.L., and Baker, D. (2003). Design of a novel globular protein fold with atomic-level accuracy. Science 302, 1364-1368.

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