Pharmacology Pharmacology

Current Topics in Pharmacology

12:30 PM, Thursday, May 14, 2009 | Room T-473 HSC
Speaker: Neil Nathanson
Topic: A Journal Club to take your breath away: The EGF Receptor Holds Its Breath: Regulation of Expression and Signaling by Hypoxia
 
Papers:

  • Franovic A, Gunaratnam L, Smith K, Robert I, Patten D, Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13092-7.  
  • Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, Marsden PA, Ohh M. Regulation of endocytosis via the oxygen-sensing pathway. Nat Med. 2009 Mar;15(3):319-24.  
  • Lee SJ, Escobedo-Lozoya Y, Szatmari EM, Yasuda R (2009) Activation of CaMKII in single dendritic spines during long-term potentiation. Nature 458:299-304.
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    Background:
     
  • Gordan JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev. 2007 Feb;17(1):71-7.
  • Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
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