Pharmacology Pharmacology

Current Topics in Pharmacology

12:30 PM, Thursday, November 5, 2009 | Room T-639 HSC
Speaker: Daniel Messinger
Topic: Tankyrase inhibition in cancer therapy: A way to right wrongs wreaked by Wnt and broken by BRCA?

  1. Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F. 2009. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461(7264):614-20.
  2. McCabe N, Cerone MA, Ohishi T, Seimiya H, Lord CJ, Ashworth A. 2009. Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer. Oncogene 28(11):1465-70.


  1. Seimiya, H. 2006. The telomeric PARP, tankyrases, as targets for cancer therapy. British Journal of Cancer 94: 341-345.
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