Pharmacology Pharmacology

Current Topics in Pharmacology

12:30 PM, Thursday, November 5, 2009 | Room T-639 HSC
Speaker: Patrick Nygren
Topic: Let's get together and feel alright: Mechanisms for allosteric activation of EGF receptor dimers

  1. Jura N., Endres N.F., Engel K., Deindl S., Das R., Lamers M.H., Wemmer D.E., Zhang X., Kuriyan J. 2009. Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 137: 1293-1307.
  2. Zhang X., Gureasko J., Shen K., Cole P.A., Kuriyan J. 2006. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125: 1137-1149.


  1. Kuriyan J., Eisenberg D. 2007. The origin of protein interactions and allostery in colocalization. Nature 450: 983-990
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