Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 12, 1997
Room T-530/530A HSC

Speaker: William A. Catterall
Topic: Tipsy Synapses: NMDA and GABA Receptors as Molecular Targets for Alcohol Intoxication

References:

  1. Lovinger DM, White G, Weight FF. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 1989 Mar 31;243(4899):1721-1724.

  2. Wang YT, Salter MW. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 1994 May 19;369(6477):233-235.

  3. Yu XM, Askalan R, Keil GJ 2nd, Salter MW. NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 1997 Jan 31;275(5300):674-678.

  4. Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, Niki H. Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 1997 Oct 24;278(5338):698-701.

  5. Nichio M, Narahashi T. Ethanol enhacement of GABA-activated chloride current in rat dorsal root ganglion neurons. Brain Res. 518: 283-286, 1990.

  6. Mihic SJ, Whiting PJ, Harris RA. Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity. Eur J Pharmacol 1994 Jul 15;268(2):209-214.

  7. Mihic SJ, Harris RA. Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics. J Pharmacol Exp Ther 1996 Apr;277(1):411-416.

  8. Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM. Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors. Proc Natl Acad Sci USA 1995 Apr 25;92(9):3658-3662.

  9. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 1997 Sep 25;389(6649):385-389.

Reviews:

  1. Tabakoff B, Hoffman PL. Alcohol addiction: an enigma among us. Neuron 1996 May; 16:909-912.


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