Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 26, 1997
Room T-530/530A HSC

Speaker: Kevin S. White
Topic: NO News is Good News: Nitric Oxide's Controversial Role as a Retrograde Messenger in Long-Term Potentiation

References:

  1. O'dell, T.J., Hawkins, R.D., Kandel, E.R., and Arancio, O. (1991) Tests of the role of two diffusable substances in long-term potentiation: Evidence for nitric oxide as a possible early retrograde messenger. Proc. Natl. Acad. Sci. USA 88:11285-11289.

  2. Bohme, G. A., Bon, C., LeMaire, M., Reibaud, M., Piot, O., Stutzmann, J.M., Doble, A., and Blanchard, J.C. (1993) Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc. Natl. Acad. Sci. USA 90:9191-9194.

  3. Williams, J.H., Li, Y G., Nayak, A., Errington, M. L., Murphy, K. P., and Bliss, T. V. (1993) The suppression of long-term potentiation in rat hippocampus by inhibitors of nitric oxide synthase is temperature and age dependent. Neuron 11(5): 877-84.

  4. O'Dell, Thomas J., Huang, Paul L., Dawson, Ted M., Dinerman, Jay L., Snyder, Solomon H., Kandel, Eric R., and Fishman, Mark C. (1994) Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science 265:542-546.

  5. Bannerman, O.M., Chapman, P.F., Kelly, P.A. T., Butcher, S.P., and Morris, R.G. (1994). Inhibition of nitric oxide synthase does not prevent the induction of long-term potentiation in vivo. The Journal of Neuroscience 14(12):7415-7425.

  6. Arancio, O., Kiebler, M., Lee, J.C., Lev-Ram, V., Tsien, R. Y., Kandel, E. R., and Hawkins, R.D. (1996) Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell 87: 1025-1035.

  7. Son, H., Hawkins, R.D., Martin, K., Kiebler, M., Huang, P.L., Fishman, M. C., and Kandel, E.R. (1996) Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell 87:1015-1023.

  8. Doyle, C., Holscher, C., Rowan, M. J., and Anwyl, R. (1996) The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo. The Journal of Neuroscience 16(1):418-424.

  9. Malen, P.L., and Chapman, P.F. (1997) Nitric oxide facilitates long-term potentiation, but not long-term depression. The Journal of Neuroscience 17(7):2645-2651.


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