Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, November 5, 1997
Room T-530/530A HSC

Speaker: Dale Chenault
Topic: We are Prion: you will be assimilated


  1. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, McCardle L, Chree A, Hope J, Birkett C, Cousens S, Fraser H, Bostock CJ . Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 1997 Oct 2;389(6650):498-501.

  2. Telling GC, Parchi P, DeArmond SJ, Cortelli P, Montagna P, Gabizon R, Mastrianni J, Lugaresi E, Gambetti P, Prusiner SB. Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science 1996 Dec 20;274(5295):2079-2082.

  3. Collinge J, Sidle KC, Meads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 1996 Oct 24;383(6602):685-690.

  4. Billeter M, Riek R, Wider G, Hornemann S, Glockshuber R, Wuthrich K. Prion protein NMR structure and species barrier for prion diseases. Proc Natl Acad Sci USA 1997 Jul 8;94(14):7281-7285.

  5. Raymond GJ, Hope J, Kocisko DA, Priola SA, Raymond LD, Bossers A, Ironside J, Will RG, Chen SG, Petersen RB, Gambetti P, Rubenstein R, Smits MA, Lansbury PT Jr, Caughey B. Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature 1997 Jul 17;388(6639):285-288.

  6. Lasmezas CI, Deslys JP, Robain O, Jaegly A, Beringue V, Peyrin JM, Fournier JG, Hauw JJ, Rossier J, Dormont D. Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science 1997 Jan 17;275(5298):402-405.

  7. Collinge J, Palmer MS, Sidle KC, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL . Unaltered susceptibility to BSE in transgenic mice expressing human prion protein. Nature 1995 Dec 21;378(6559):779-783.


  1. Prusiner SB. The prion diseases. Sci Am 1995 Jan;272(1):48-51.

  2. Prusiner SB. Prion diseases and the BSE crisis. Science 1997 Oct 10;278(5336):245-251.

Non-traditional Sources:

  1. Nobel Prize Page: Check under physiology and medicine and click under Stanley Prusiner for links to the above two articles and other related pages.

1997-1998 Journal Club Archive

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