Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, December 3, 1997
Room T-530/530A HSC

Speaker: Joseph A. Beavo
Topic: NF-KB Linked Signal Transduction Pathways


  1. Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., Siebenlist, U. (1995). Control of IkB-alpha; Proteolysis by Site-Specific Signal-Induced Phosphorylation. Science 267:1485.

  2. Chen, Z., Hagler, J., Palombella, V., Melandri, F., Scherer, D., Ballard, D., Maniatis, T. (1995). Signal-induced site-specific phosphorylation targets IkB alpha to the ubiquitin-proteasome pathway. Genes and Development 9:1586-1597.

  3. Chen, Z., Parent, L., Maniatis, T. (1996). Site-Specific Phosphorylation of IkB alpha by a Novel Ubiquitination-Dependent Protein Kinase Activity. Cell 84:853-862.

  4. Liu, Z., Hsu, H., Goeddel, D., Karin, M. (1996). Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-kB Activation Prevents Cell Death. Cell 87:565-576.

  5. Lee, F., Hagler, J., Chen, Z., Maniatis, T. (1997). Activation of the IkB alpha Kinase Complex by MEKK1, a Kinase of the JNK Pathway. Cell 88:213-222.

  6. Malinin, N., Boldin, M., Kovalenko, A., Wallach, D. (1997). MAP3K-related kinase involved in NF-kB induction by TNF, CD95 and IL-1. Nature 385:540.

  7. R&ecutegnier, C., Song, H., Gao, X., Goeddel, D., Cao, Z., Rothe, M. (1997). Identification and Characterization of an IkB Kinase. Cell 90:373-383.

  8. DiDonato, J., Hayakawa, M., Rothwarf, D., Zandi, E., Karin, M. (1997). A cytokine-responsive IkB kinase that activates the transcription factor NF-kB. Nature 388:543.

  9. Zandi, E., Rothwarf, D., Delhase, M., Hayakawa, M., Karin, M. (1997). The IkB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKµ and IKKb, Necessary for IkB Phosphorylation and NF-kB Activation. Cell 91:243-252.


  1. Verma, I., Stevenson, J., Schwartz, E., Van Antwerp, D., Miyamoto, S. (1995). Rel/NF-kB/IkB family: intimate tales of association and dissociation. Genes and Development 9:2723-2735.

  2. Epstein, F. (1997). Nuclear Factor - kB Š A Pivotal Transcription Factor in Chronic Inflammatory Diseases. New England Journal of Medicine, April 10, 1997.

  3. Stancovski, I., Baltimore, D. (1997). NF-kB Activation: The IkB Kinase Revealed?. Cell 91:299-302.

1997-1998 Journal Club Archive

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