Pharmacology 514:
Current Topics in Pharmacology
Journal Club

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 14, 1998
Room T-530/530A HSC

Speaker: Renée Chmelar
Topic: Taking a JAB at cytokine signaling: Negative Regulation by a novel protein family

References:

1. Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J 1995 Jun 15;14(12):2816-2826

2. Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A, Yoshimura A. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 1997 May 1;89(9):3148-3154

3. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signalling. Nature 1997 Jun 26;387(6636):917-921

4. Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997 Jun 26;387(6636):921-924

5. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997 Jun 26;387(6636):924-929

6. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A. Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun 1997 Oct 20;239(2):439-446

Reviews:

1. Aman MJ, Leonard WJ. Cytokine-inducible signaling inhibitors. Curr Biol 1997 Dec 1;7(12):R784-R788

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