Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 21, 1998
Room T-530/530A HSC

Speaker: Laurie Nadler
Topic: Regulation of mitosis by a novel protein isomerase


  1. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld J-U, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. (1997) Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science 278:1957-1960.

  2. Ranganathan R, Lu KP, Hunter T, Noel JP (1997) Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89:875-886.

  3. Lu KP, Hanes SD, Hunter T (1996) A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380:544-547.

  4. Lu KP, Hunter T (1995) Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81:413-424.

  5. Ye XS, Xu G, Pu RT, Fincher RR, McGuire SL, Osmani AH, Osmani SA (1995) The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: Coordination of two mitosis promoting kinases. EMBO J. 14:986-994.


  1. Fry AM, Nigg EA (1995) The NIMA kinase joins forces with cdc2. Curr. Biol. 5:1122-1124.

  2. Nigg EA (1995) Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle. Bioessays 17:471-480.

1997-1998 Journal Club Archive

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