Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 11, 1998
Room T-530/530A HSC

Speaker: Rejean L. Idzerda
Topic: SGS1: A new gene for an age old problem?


  1. Gangloff S, McDonald JP, Bendixen C, Arthur L, Rothstein R. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol 1994 Dec;14(12):8391-8398.

  2. Watt PM, Hickson ID, Borts RH, Louis EJ. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics 1996 Nov;144(3):935-945.

  3. Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD. Positional cloning of the Werner's syndrome gene. Science 1996 Apr 12;272(5259):258-262.

  4. Sinclair DA, Mills K, Guarente L. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 1997 Aug 29;277(5330):1313-1316.

  5. Sinclair DA, Guarente L. Extrachromosomal rDNA circles~a cause of aging in yeast. Cell 1997 Dec 26;91(7):1033-1042.


  1. Guarente L. Link between aging and the nucleolus. Genes Dev 1997 Oct 1;11(19):2449-2455.

1997-1998 Journal Club Archive

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