Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 25, 1998
Room T-530/530A HSC

Speaker: Sandy Bajjalieh
Topic: Cell's Apoppin': The Role of Sphingolipids in Cell Death and Proliferation

References:

  1. Watts JD, Gu M, Polverino AJ, Patterson SD, Aebersold R. Fas-induced apoptosis of T cells occurs independently of ceramide generation. Proc Natl Acad Sci USA 1997 Jul 8;94(14):7292-7296.

  2. Tepper AD, Cock JG, de Vries E, Borst J, van Blitterswijk WJ. CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition. Biol Chem 1997 Sep 26;272(39):24308-24312.

  3. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996 Mar 7;380(6569):75-79.

  4. Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Lang F, Gulbins E. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem 1997 Aug 29;272(35):22173-22181.

  5. De Maria R, Lenti L, Malisan F, d'Agostino F, Tomassini B, Zeuner A, Rippo MR, Testi R. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 1997 Sep 12;277(5332):1652-1655.

  6. Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J, Weichselbaum RR. Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res 1997 Apr 1;57(7):1270-1275.

  7. Michael JM, Lavin MF, Watters DJ. Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling. Cancer Res 1997 Aug 15;57(16):3600-3605.

  8. Gomez-Munoz A, Duffy PA, Martin A, O'Brien L, Byun HS, Bittman R, Brindley DN. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol 1995 May;47(5):833-839.

  9. Gomez-Munoz A, Frago LM, Alvarez L, Varela-Nieto I. Stimulation of DNA synthesis by natural ceramide 1-phosphate. Biochem J 1997 Jul 15;325( Pt 2):435-440.

  10. Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996 Jun 27;381(6585):800-803.

Reviews:

  1. Testi R. Sphingomyelin breakdown and cell fate. Trends Biochem Sci 1996 Dec;21(12):468-471.

  2. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996 Dec 13;274(5294):1855-1859.


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