Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 29, 1998
Room T-530/530A HSC

Speaker: Todd Scheuer
Topic: Two heads are better than one: The kinesin superfamiliy and cellular transport


  1. Kozielski F, Sack S, Marx A, Thormählen M, Schönbrunn E, Blou V, Thompson A, Mandelkow E-M, Mandelkow E. (1997) The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91:985-994.

  2. Hancock WO, Howard J. (1998) Processivity of the motor protein kinesin requires two heads. J. Cell. Biol. 140:1395-1405.

  3. Romberg L, Pierce DW, Vale RD. (1998) Role of the kinesin neck region in processive microtubule-based motility. J. Cell Biol. 140:1407-1416.

  4. Henningsen U, Schliwa M. (1997) Reversal in the direction of movement of a molecular motor. Nature 389:93-96.

  5. Case R., Pierce DW., Hom-Booher N., Hart CL, Vale RD (1997) The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell 90:959-966,

  6. Lindesmith L., McIlvain JM Jr., Argon Y, Sheetz M. (1997) Phosphotransferases associated with kinesin motor activity. J. Biol. Chem. 272:22929-22933.

  7. Gindhart JG Jr., Desai CJ, Beushausen, S, Zinn K, Goldstein LSB (1998) Kinesin light chains are essential for axonal transport in Drosophila. J. Cell Biol. 141:443-454.


  1. Hirokawa N. (1998) Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279:519-526.

  2. Lohman TM, Thorn K, Vale RD. (1998) Staying on track: Common features of DNA helicases and microtubule motors. Cell 93:9-12.

  3. Block SM. (1998) Kinesin: What gives? Cell 93:5-8.

Other Resources:

  1. Kinesin Home Page.

1997-1998 Journal Club Archive

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