Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, April 8, 1998
Room T-530/530A HSC

Speaker: Sherri Rogalski
Topic: The role of melanocortin-4 receptor and the novel orexin receptor in appetite. Why Weight Watchers can't fool Mother Nature

References:

  1. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997 Jan 10;88(1):131-141.

  2. Boston BA, Blaydon KM, Varnerin J, Cone RD. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997 Nov 28;278(5343):1641-1644.

  3. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997 Jan 9;385(6612):165-168.

  4. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998 Feb 20;92(4):573-585.

  5. Friedman JM. The alphabet of weight control. Nature 1997 Jan 9;385(6612):119-120.

Reviews:

  1. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 1998 Feb 20;92(4):437-440.

  2. Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996 Nov 1;87(3):377-389.

  3. Stadel JM, Wilson S, Bergsma DJ. Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery. Trends Pharmacol Sci 1997 Nov;18(11):430-437.


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