Pharmacology 514:
Current Topics in Pharmacology
Journal Club


Announcements

Schedule

Faculty

Instructions for
Speakers


JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, December 9, 1998
Room T-530/530A HSC

Speaker: Traci Hilton
Topic: Alzheimers and apoptosis. Presenilins: the saga continues

References:

  1. Czech, C., Lesort, M., Tremp, G., Terro, F., Blanchard, V., Schombert, B., Carpentier, N., Dreisler, S., Bonici, B., Takashima, A., Moussaoui, S., Hugon, J., and Pradier, L. (1998) Characterization of human presenilin-1 transgenic rats: Increased sensitivity to apoptosis in primary neuronal cultures. Neuroscience 87(2), 325-336.

  2. Grunberg, J., Walter, J., Loetscher, H., Deuschle, U., Jacobsen, H., and Haass, C. (1998) Alzheimers disease associated presenilin-1 holoprotein and its 18-20 kDA C-terminal fragment are death substrates for proteases of the capsase family. Biochemistry 37, 2263-70.

  3. Roperch, J., Alvaro, V., Prieur, S., Tuynder, M., Nemani, M., Lethrosne, F., Piouffre, L., Gendron, M., Israeli, D., Dausett, J., Oren, M., Amson, R., and Telerman, A. (1998) Inhibition of presenilin-1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat Med 4(7) 835-8.

  4. Vito, P., Ghayur, G., DAdamio, L. (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and capsase-3 cleavage. J Biol Chem 272(45), 28315-20.

  5. Vito, P., Wolozin, B., Ganjei, J., Iwasaki, K., Lacana, E., and DAdamio, L. (1996) Requirement of the familial Alzheimers disease gene PS2 for apoptosis. Opposing effects of ALG-3. J Biol Chem 271(49), 31025-8.

  6. Vito, P., Lacana, E., and DAdamio, L. (1996) Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimers disease gene ALG-3. Science 271(5248), 521-5.

  7. Wolozin, B., Alexander, P., and Palacino, J. (1998) Regulation of apoptosis by presenilin-1. Neurobiol Aging 19(1S), S23-27.

  8. Zhang, Z., Hartman, HJ., Do, V., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H., Saftig, P., Strooper, B., He, X., and Yankner, B. (1998) Destabilization of b-catenin by mutation in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.

Reviews:
  1. Kovacs, D., and Tanzi, R. (1998) Monogenic determinants of familial Alzheimers disease: presenilin-1 mutations. Cell Mil Life Sci 54, 902-909.

  2. Renbaum, P., and Levy-lahad, E. (1998) Monogenic determinants of familial Alzheimers disease: presenilin-2 mutations. Cell Mil Life Sci 54, 910-919.

  3. Velez-Pardo, C., Jimenez Del Rio, M., Lopera, F. (1998) Familial Alzheimers disease: Oxidative stress, b-amyloid, presenilins, and cell death. Gen Pharmac 31(5), 675-81.


1998-1999 Journal Club Archive
Other
Pharmacology
Courses

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives