Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, December 9, 1998
Room T-530/530A HSC

Speaker: Traci Hilton
Topic: Alzheimers and apoptosis. Presenilins: the saga continues


  1. Czech, C., Lesort, M., Tremp, G., Terro, F., Blanchard, V., Schombert, B., Carpentier, N., Dreisler, S., Bonici, B., Takashima, A., Moussaoui, S., Hugon, J., and Pradier, L. (1998) Characterization of human presenilin-1 transgenic rats: Increased sensitivity to apoptosis in primary neuronal cultures. Neuroscience 87(2), 325-336.

  2. Grunberg, J., Walter, J., Loetscher, H., Deuschle, U., Jacobsen, H., and Haass, C. (1998) Alzheimers disease associated presenilin-1 holoprotein and its 18-20 kDA C-terminal fragment are death substrates for proteases of the capsase family. Biochemistry 37, 2263-70.

  3. Roperch, J., Alvaro, V., Prieur, S., Tuynder, M., Nemani, M., Lethrosne, F., Piouffre, L., Gendron, M., Israeli, D., Dausett, J., Oren, M., Amson, R., and Telerman, A. (1998) Inhibition of presenilin-1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat Med 4(7) 835-8.

  4. Vito, P., Ghayur, G., DAdamio, L. (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and capsase-3 cleavage. J Biol Chem 272(45), 28315-20.

  5. Vito, P., Wolozin, B., Ganjei, J., Iwasaki, K., Lacana, E., and DAdamio, L. (1996) Requirement of the familial Alzheimers disease gene PS2 for apoptosis. Opposing effects of ALG-3. J Biol Chem 271(49), 31025-8.

  6. Vito, P., Lacana, E., and DAdamio, L. (1996) Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimers disease gene ALG-3. Science 271(5248), 521-5.

  7. Wolozin, B., Alexander, P., and Palacino, J. (1998) Regulation of apoptosis by presenilin-1. Neurobiol Aging 19(1S), S23-27.

  8. Zhang, Z., Hartman, HJ., Do, V., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H., Saftig, P., Strooper, B., He, X., and Yankner, B. (1998) Destabilization of b-catenin by mutation in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.

  1. Kovacs, D., and Tanzi, R. (1998) Monogenic determinants of familial Alzheimers disease: presenilin-1 mutations. Cell Mil Life Sci 54, 902-909.

  2. Renbaum, P., and Levy-lahad, E. (1998) Monogenic determinants of familial Alzheimers disease: presenilin-2 mutations. Cell Mil Life Sci 54, 910-919.

  3. Velez-Pardo, C., Jimenez Del Rio, M., Lopera, F. (1998) Familial Alzheimers disease: Oxidative stress, b-amyloid, presenilins, and cell death. Gen Pharmac 31(5), 675-81.

1998-1999 Journal Club Archive

Announcements | Schedule | Faculty | Instructions for Speakers | JClub Archives