Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 13, 1999
Room T-530/530A HSC

Speaker: Elizabeth Dunphy
Topic: Tit for Tat: Gimme NTPs and I'll give you Elongatin

References:

  1. Ippolito, J. and Steitz, T. (1998) A 1.3-A resolution crystal structure of the HIV-1 transactivation response region RNA stem reveals a metal ion-dependent bulge conformation. PNAS 95(17): 9819-24.

  2. Mancebo, H., et. al. (1997) P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes and Development 11: 2633-44.

  3. Marshall, N., et. al. (1996) Control of RNA Polymerase II Elongation by a Novel Carboxy-Terminal Domain Kinase. J. Biol. Chem. 271(43): 27176-83.

  4. Parada, C. and Roeder, R. (1996) Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature 384:375-8.

  5. Wei, P., et. al. (1998) A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA. Cell 92: 451-62.

  6. Yang, X., Herrmann, C., and Rice, A. (1996) The Human Immunodeficiency Virus Tat Proteins Specifically Associate with TAK In Vivo and Require the Carboxyl-Terminal Domain of RNA Polymerase II for Function. J. Virol. 70: 4576-84.

  7. Zhu, Y., et. al. (1997) Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation. Genes and Development 11:2622-32.



Reviews:
  1. Cullen, B. (1998) HIV-1 auxiliary proteins: making connections in a dying cell. Cell 93(5): 685-92.

  2. Yankulov, K. and Bentley, D. (1998) Transcriptional control: Tat cofactors and transcriptional elongation. Current Biology 8(13): R447-9.


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