Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, January 27, 1999
Room T-530/530A HSC

Speaker: Brian Hale
Topic: Great Expectations: The role of PIP2 in Regulation of KATP


  1. Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B "PIP2 and PIP as determinants for ATP inhibition of KATP channels." Science 1998 Nov 6;282(5391):1141-4

  2. Shyng SL, Nichols CG. "Membrane phospholipid control of nucleotide sensitivity of KATP channels" Science 1998 Nov 6;282(5391):1138-41

  3. Huang CL, Feng S, Hilgemann DW. "Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma." Nature 1998 Feb 19;391(6669):803-6

  4. Sui JL, Petit-Jacques J, Logothetis DE. "Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates." Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1307-12

  5. Fan Z, Makielski JC. "Anionic phospholipids activate ATP-sensitive potassium channels." J Biol Chem 1997 Feb 28;272(9):5388-95

  6. Yang, X., Herrmann, C., and Rice, A. (1996) The Human Immunodeficiency Virus Tat Proteins Specifically Associate with TAK In Vivo and Require the Carboxyl-Terminal Domain of RNA Polymerase II for Function. J. Virol. 70: 4576-84.

  7. A. Terzic, R. T. Tung, A. Inanobe, T. Katada, and Y. Kurachi. "G Proteins Activate ATP-sensitive K+ Channels by Antagonizing ATP- Dependent Gating." Neuron 1994 12: 885-893

  1. Ashcroft FM. "Exciting times for PIP2." Science 1998 Nov 6;282(5391):1059-60

  2. Toker A. "The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate." Curr. Op. Cell Bio. 1998, 10:254-261

  3. Ashcroft FM, Gribble FM. "Correlating structure and function in ATP-sensitive K+ channels." Trends Neurosci 1998 Jul;21(7):288-94

1998-1999 Journal Club Archive

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