Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 10, 1999
Room T-530/530A HSC

Speaker: Amanda Kalaydjian
Topic: The Ins and outs of G2-M Checkpoint Regulation by a kinase, a phsphatase, and a 14-3-3 protein

References:

  1. Ford, J.C. et al. (1994) 14-3-3 Protein Homologs Required for the DNA Damage Checkpoint in Fission Yeast. Science 265: 533-535.

  2. Furnari, B., Rhind, N. and Russell, P. (1997) CDC25 Mitotic Induced Targeted by Chk1 DNA Damage Checkpoint Kinase. Science 277: 1495-1497.

  3. Hermeking, H et al. (1997) 14-3-3 Is a p53-Regulated Inhibitor of G2/M Progression. Molecular Cell. 1: 3-11.

  4. Kumagai, A., Yakowec, P.S. and Dunphy, W.G. (1998) 14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 in Xenopus Egg Extracts. Mol. Biol of the Cell 9: 345-354.

  5. Lopez-Girona, A. et al. (1999) Nuclear Localization of Cdc25 is Regulated by DNA Damage and a 14-3-3 Protein. Nature 397: 172-175.

  6. Peng, C-Y. et al. (1997) Mitotic and G2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216. Science 277: 1501-1504.

  7. Toyoshima, F. et al. (1998) Nuclear Export of cyclin B1 and its possible role in the DNA Damage-Induced G2 Checkpoint. EMBO 17: 2728-2735.

  8. Yang, J. et al. (1998) Control of Cyclin B1 Localization through Regulated Binding of the Nuclear Export Factor CRM1. Genes and Dev. 12: 2131-2143.



Reviews:
  1. Gorlich, D. and Mattaj, I.W. (1996) Nucleocytoplasmic Transport. Science 271: 1513-1518.

  2. Nurse, P. (1997). Checkpoint Pathways Come of Age. Cell 91: 865-867.

  3. Pines, J. (1999). Checkpoint on the Nuclear Frontier. Nature 397: 104-105.


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