Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 17, 1999
Room T-530/530A HSC

Speaker: Bill Watt
Topic: Polyglutamine repeats in Huntingtin's and other Nondegenerative Diseases: How Objectional is Nuclear Inclusion?

References:

  1. Moulder KL, Onodera O, Burke JR, Strittmatter WJ, Johnson EM Jr. (1999) Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine Length. J. Neuroscience 19(2):705-715.

  2. Faber PW, Alter JR, MacDonald ME, Hart AC (1999) Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabitis elegans sensory neuron. Proc. Natl. Acad. Sci USA (96):79-184.

  3. Warrick JM, Paulson HL, Gray-Board GL, Bui QT, Fischbeck KH, Pittman RN, Bonini NM (1998) Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila. Cell 98:939-949.

  4. Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, MacDonald ME, Zipursky SL (1998) Polyglutamine-Expanded Human Huntingtin Transgenes Induce Degeneration of Drosophila Photoreceptor Neurons. Neuron 21:633-642.

  5. Saudou F, Finkbeiner S, Devys D, Greenberg ME (1998) Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions. Cell 95:55-66.

  6. Li SH, Gutekunst CA, Hersch SM, Li XJ (1998) Interaction of Huntingtin-Associated Protein with Dynactin P150Glued. J. Neuroscience 18(4):1261-1269.

  7. Sittler A, Walter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (1998) SH3GL3 Associates with the Huntingtin Exon 1 Protein and Promotes the Formation of Polygln-Containing Protein Aggregates. Mol. Cell 2:427-436.

  8. Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (1998) Huntingtin interacts with a family of WW domain proteins. Human Mol. Gen. 7(9):1463-1474.

  9. DePace AH, Santoso A, Hillner P, Weissman JS (1998) A Critical Role for Amino-Terminal Glutamine/Asparagine Repeats in the Formation and Propagation of a Yeast Prion. Cell 93:1241-1252.



Reviews:
  1. Ross, Christopher A. (1997) Intranuclear Neuronal Inclusions: A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases? Neuron 19:1147-1150.

  2. Hardy J, Gwinn-Hardy K (1998) Genetic Classification of Primary Neurodegenerative Disease. Science 282:1075-1078.

  3. Price DL, Sisodia SS, Borchelt DR (1998) Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models. Science 282:1079-1083.


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