Pharmacology 514:
Current Topics in Pharmacology
Journal Club




Instructions for

JClub Archive

Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, February 3, 1999
Room T-530/530A HSC

Speaker: Colleen Niswender
Topic: Killing the messenger: RNA mutations as a mechanism for neurodegeneration


  1. Rothstein J.D., Martin L.J., Kuncl R.W. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. (1992) New Eng. J. Med. 326; 1464-1468.

  2. Shaw P.J., Chinnery R.M., Ince P.G. [3H] D-Aspartate binding sites in the normal spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. (1994) Brain Res 655; 195-201.

  3. Rothstein J.D., Van Kammen M., Levey A.I., Martin L.J., Kuncl R.W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. (1995) Ann Neurol 38; 73-84.

  4. Bristol L.A., Rothstein J.D. Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. (1996) Ann Neurol 39; 676-679.

  5. Aoki M., Lin, C.L., Rothstein, J.D., Geller, B.A., Hosler, B.A., Munsat, T.L., Horvitz, H.R., Brown, R.H. Jr. Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. (1998) Ann Neurol 43; 645-653.

  6. Lin C.-H. G, Bristol L.A., Jin L., Dykes-Hoberg M., Crawford T., Clawson L., Rothstein J.D. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. (1998) Neuron 20; 589-602.

  7. Evans D.A.P., Van der Kleu A.A.M., Sonnemans M.A.F., Burbach J.P.H., Van Leeuwen F.W. Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons. Proc. Natl. Acad. Sci. 91; 6059-6063.

  8. Van Leeuwen F.W., de Kleijn, D.P., van den Hurk, H.H., Neubauer, A., Sonnemans, M.A., Sluijs, J.A., Koycu, S., Ramdjielal, R.D.J., Salehi, A., Martens, G.J.M, Grosveld, F.G., Peter, J., Burbach, H., Hol, E.M. Frameshift mutants of b amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. (1998) Science 279; 242-247.

  1. Grabowski P. Splicing regulation in neurons: tinkering with cell-specific control. (1998) Cell 92; 709-712.

  2. Van Leeuwen F., Burbach J. P.H., Hol E.M. Mutations in RNA: a first example of molecular misreading in Alzheimer's disease. (1998) Trends Neurosci 21; 331-335.

  3. Alves-Rodrigues A., Gregori L., Figueiredo-Pereira M.E. Ubiquitin, cellular inclusions, and their role in neurodegeneration. (1998) Trends Neurosci21; 516-520.

  4. Vogel G. Possible new cause of Alzheimer's disease found. (1998) Science 279; 174.

1998-1999 Journal Club Archive

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