Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 19, 1999
Room T-530/530A HSC

Speaker: Susan Hamilton
Topic: Yabba GABAB Do! Activation Takes Two - GABAB Receptors as GPCR-Heterodimers

References:

  1. Couve A, Filippov AK, Connolly CN, Bettler B, Brown DA, and Moss SJ. (1998) Intracellular Retention of Recombinant GABAB Receptors. J. Biol. Chem. 273:26361-26367.

  2. Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, Dai M, Yao W-J, Johnson M, Gunwaldsen C, Huang L-Y, Tang C, Shen Q, Salon JA, Morse K, Laz T, Smith KE, Nagarathnam D, Noble SA, Branchek TA, and Gerald C. (1998) CABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2. Nature 396:674-678.

  3. Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, and Bettler B. (1997) Expression cloning of GABAB receptors uncovers similarity to metabotropic gluatmate receptors. Nature 386:239-246.

  4. Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, and Bettler B. (1998) GABAB-receptor subtypes assemble into functional heteromeric complexes. Nature 396:683-687.

  5. Kaupmann K, Schuler V, Mosbacher J, Bischoof S, Bittiger H, Heid J, Froestl W, Leonhard S, Pfaff T, Karschin A, and Bettler B. (1998) Human g-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. Proc. Natl. Acad. Sci. USA 95:14991-14996

  6. Kuner R, Köhr G, Grünewald S, Eisenhardt G, Bach A, and Kornau H-C. (1999) Role of Heteromer Formation in GABAB Receptor Function. Science 283:74-77.

  7. Ng GYK, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF Jr., Evans JF, Bonner TI, and O'Neill GP. (1999) Identification of a GABAB Receptor Subunit gb2, Required for Functional GABAB Receptor Activity. J. Biol. Chem. 274:7607-7610.

  8. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, and Marshall FH. (1998) Heterodimerization is required for the formation of a functional GABAB receptor. Nature 396:679-682.

Reviews:
  1. Huang EP. (1999) Synaptic Plasticity: Regulated translation in dendrites. Curr. Biol. 9:R168-R170.

  2. Kuhl D and Skehel P. (1998) Dendritic localization of mRNAs. Curr. Opin. Neurobiol. 8:600-606.


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