Pharmacology 514:
Current Topics in Pharmacology
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Current Topics in Pharmacology
Phcol 514
12:30 PM, Wednesday, May 5, 1999
Room T-530/530A HSC

Speaker: Neil Nathanson
Topic: When You're Hot, You're Hot: The Vanilloid Receptor, an Ion Channel Activated by Heat AND Hot Pepper

References:

  1. Cesare P and McNaughton P. (1996) A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc. Natl. Acad. Sci. USA 93:15435-15439.

  2. Oh U, Hwang SW, and Kim D. (1996) Capsaicin Activates a Nonselective Cation Channel in Cultured Neonatal Rat Dorsal Root Ganglion Neurons. J. Neurosci. 16:1659-1667.

  3. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, and Julius D. (1997) Nature 389:816-824.

  4. Tominaga M, Caterina MJ, Malmberg AB, Rosen, TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, and Julius D. (1998) The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli. Neuron 21:531-543.

  5. Jung J, Hwang SW, Kwak J, Lee S-Y, Kang C-J, Kim WB, Kim D, and Oh U. (1999) Capsaicin Binds to the Intracellular Domaon of the Capsaicin-Activated Ion Channel. J. Neurosci. 19:529-538.

  6. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, and Julius J. (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436-441.

  7. Suzuki M, Sato J, Kutsuwada K, Ooki G, and Imai M. (1999) Cloning of a Stretch-inhibitable Nonselective Cation Channel. J. Biol. Chem. 274:6330-6335.



Reviews:
  1. Szallasi A. (1994) The Vanilloid (Capsaicin) Receptor: Receptor Types and Species Differences. Gen. Pharmac. 25:223-243.

  2. Kress M and Zeilhofer HU. (1999) Capsaicin, protons and heat: new excitement about nociceptors. Trends Pharmacol. Sci. 20:112-8.


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