Hadrian VI (1522-23)
      Dutch Pope; last non-ltalian pope until 20th C. Polish Pope
 Clement VII Medici (1523-34)
            prisoner during Sack of Rome (1527)
            by the German troops of Emperor Charles V Hapsburg
 Paul III (1534-1549) Farnese, old Roman family, builds Palazzo Farnese
             finally calls Council of Trent (1543-63)   (off Campo dei Fiori)

Dwarfing of italy, 1494-1527
    French (Valois) invasions of Italy:
      1494 Charles VIII
      1498 Louis XII called in by Venice against Milan
      1515 Francis I -victory at Marignano, occupation of Milan
             defeated at Pavia 1525 by Charles V
      1519 Imperial election:  Hapsburg Charles I  of  Spain 
                        becomes Emperor Charles V  of Holy Roman Empire
             Leo X makes alliance with Charles V against France

Hapsburg - Valois Wars 1522-1529
     1522-4 struggle for Milan between France & Empire
      1525   BATTLE OF PAVIA:
                Imperial victory, Francis taken prisoner
                Pope & Italian states begin to fear Imperial victory
      1528  TREATY OF MADRID:
               Francis renounces claims to Burgundy,
               Netherlands, Italy; Francis marries Charles sister
      1526   LEAGUE OF COGNAC: broad alliance against Charles V by
                France, Papacy, Italians (Milan, Florence, Venice)
                due to fear of Imperial power taking over all of Italy
                (note that Papacy has now changed sides from Empire to France)

1527  SACK OF ROME: lasts six months
               by German Imperial troops, many Lutheran  
                occupy the Vatican, used to house troops
                worst Sack of city in terms of people killed
      Pope Clement VII (Medici) prisoner in Castel Sant'Angelo

 Restoration of Florentine Republic, 1527-1530 (occurs in year of Machiavelli's death)
        1527 invasion of Italy by Hapsburg troops at war with France & Pope;
                overthrow of Medici (allies of Pope); restored as Grand Dukes 1530

1529 PEACE OF CAMBRAI:
            Francis renounces claims to Flanders & ltaly
            Charles renounces claim to Burgundy
      1529      PEACE OF BARCELONA
            Pope confirms Imperial (Hapsburg) claim to Naples
1530  Charles crowned Holy Roman Emperor by Pope Clement VII
            ceremony held in Bologna because Rome is disaster zone