Advanced Biochemistry 530

Last Updated: December 5

Autumn Quarter, 2016

BIOC530 - Introduction to Structural Biology

David Baker

Biochemistry Department

University of Washington

 

Announcements:

 

Location

Lectures will be held on Mondays, Wednesdays and Fridays in Loew Hall (LOW) 201, from 11:30AM-12:20PM

Lecture Schedule

  

Week	Date	Monday	Wednesday	Friday
1	9/26 – 9/30	No Class	Forces I (DB)	Forces II (DB)
2	10/3 - 10/7	Forces III (DB)	Protein Folding in vivo (DB)	Membrane Proteins (WH)
5	10/24 - 10/28	The RNA World I (AW)  RNA folding movie	The RNA World II (AW)  Molecular Fossils Article	The RNA World III (AW)
6	10/31 - 11/4	Sequence Comparison (DB)	Structure Prediction (DB)	Electron Microscopy (DV)
7	11/7 - 11/11	NMR I (RK) Reading assignment	NMR II (RK)	No Class (Veterans Day)
8	11/14 - 11/18	NMR III (RK)	Protein Dynamics I (VD)	Protein Dynamics II (VD)
9	11/21 - 11/25	Protein Design (DB) Design movie	Discussion Section	No Class (Thanksgiving)
10	11/28 – 12/2	Signaling and Protein Modification I (NZ)	Signaling and Protein Modification II (NZ)	Viruses (WH)
11	12/5 - 12/9	Structure-Based Drug Design (WH)	Chemical Biology I (DM)	Chemical Biology II (DM)
12	12/12 - 12/16	Exam

 

Instructors	E-mail
David Baker	dabaker@u.washington.edu
Ethan Merritt	merritt@u.washington.edu
Valerie Daggett	daggett@u.washington.edu
Rachel Klevit	klevit@u.washington.edu
Wim Hol	wghol@u.washington.edu
Alan Weiner	amweiner@u.washington.edu
Dustin Maly	maly@chem.washington.edu
Ning Zheng   David Veesler	nzheng@u.washington.edu   dveesler@uw.edu

 

Teaching Assistant	E-mail
Allison Maker	makera@uw.edu

 

Grading

 

Your final grade will be based on weekly homework assignments (60%), class participation (10%), and the final exam (30%).

Homework

All graded homework assignments will be returned in class. 

 

 

[ Homework #1 ] Assigned 10/7, due 10/17 in class
Homework #1

 

[ Homework #2 ] Assigned 10/15, due 10/24 in class

Homework #2

 

[ Homework #3 ]  Assigned 10/29, due 11/7 in class

Homework #3

 

[ Homework #4 ]  Assigned 11/7, due 11/16 in class

Homework #4

 

Resources

tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: Implications for the origin of protein synthesis 

The genemic tag hypothesis: what molecular fossils tell us about the evolution of tRNA 

NMR Seminar Assignment 

 

 

 

Office Hours

 

Office hours are held each week at 10:15 on Fridays in the Engineering Library study room 202 or 203 unless otherwise noted. Please email Allison at makera@uw.edu to make an appointment.

    

 

Recommended Reading

 

Protein Physics, Alexei Finkelstein, Oleg Ptitsyn

Introduction to Protein Structure, Carl Brenden and John Tooze

Structure and Mechanism in Protein Science, Alan Fersht

Proteins: Structure and Molecular Properties, Thomas Creighton

 

 

 

 

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