Lectures will be held on Mondays, Wednesdays and Fridays in the Mechanical Engineering Building (MEB), Room 248, from 11:30AM-12:20PM

Lecture Schedule

Week Date Monday Wednesday Friday
1 9/28 - 10/2 No Class Forces I (DB) Forces II (DB)
2 10/5 - 10/9 Forces III (DB) X-Ray Crystallography I (EM) X-Ray Crystallography II (EM)
3 10/12 - 10/16 X-Ray Crystallography III (EM) X-Ray Crystallography IV (EM) Protein Folding I (DB)
4 10/19 - 10/23 Protein Folding II (DB)  Protein Folding in vivo (DB) The RNA World I (AW) 
RNA folding movie
5 10/26 - 10/30 The RNA World II (AW)  The RNA World III (AW)  Sequence Comparison (DB)
6 11/2 - 11/6 Structure Prediction (DB)
Coevolution Analysis(SO)
7 11/9 - 11/13 NMR III (RK) No Class(Veterans Day) Protein Dynamics I (VD)
8 11/16 - 11/20 Protein Dynamics II (VD) Electron Microscopy (WH) Viruses (WH) 
9 11/23 - 11/27 Protein Design (DB)
Design movie
Discussion Section No Class(Thanksgiving)
10 11/30 - 12/4 Signaling and Protein Modification I (NZ) Signaling and Protein Modification II (NZ) Membrane Proteins (WH)
11 12/7 - 12/11 Structure-Based Drug Design (WH) Chemical Biology I (DM) Chemical Biology II (DM)
12 12/14 - 12/18 Exam
David Baker
Ethan Merritt
Valerie Daggett
Rachel Klevit
Wim Hol
Alan Weiner
Dustin Maly
Ning Zheng
Teaching Assistant
Jiayi Dou


Your final grade will be based on weekly homework assignments (60%), class participation (10%), and the final exam (30%).


All graded homework assignments will be returned in class.

[ Homework #1 ] Assigned 10/5, due 10/12 in class
Homework #1

[ Homework #2 Solutions]
Homework #2 Solutions

[ Homework #3 ] Assigned 10/30, due 11/6 in class
Homework #3

[ Homework #4 ] Assigned 11/6, due 11/13 in class
Homework #4

[ Homework #5 ] Assigned 11/3, due 11/16 in class
Homework #5


tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: Implications for the origin of protein synthesis

The genemic tag hypothesis: what molecular fossils tell us about the evolution of tRNA

NMR Seminar Assignment

Office Hours

Office hours are held each week in Health Sciences J-475 on Fridays from 9am to 10am. Please email Jiayi at to make an appointment.


Recommended Reading

Protein Physics, Alexei Finkelstein, Oleg Ptitsyn
Introduction to Protein Structure, Carl Brenden and John Tooze
Structure and Mechanism in Protein Science, Alan Fersht
Proteins: Structure and Molecular Properties, Thomas Creighton

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