Session Schedule - Spring 2003

March 31, 2003

"Introduction" and "Epidemiologic Criteria for Selection and Evaluation of Biomarkers"

Session Leader: Steve Schwartz 

 

Readings:

 

Hulka BS. Epidemiological studies using biological markers: issues for epidemiologists. Cancer Epidemiol Biom Prev 1991;1:13-19.

Pearce NE, de Sanjose S, Boffeta P, Kogevinas M, Saracci R, Savitz D. Limitations of Biomarkers of Exposure in Cancer Epidemiology. Epidemiology 1995; 6:190-194.

Schulte PA. Chapter 1. (Schulte PA. A Conceptual and Historical Framework for Molecular Epidemiology. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

Wilcox AJ. Molecular Epidemiology: Collision of two cultures. Epidemiology 1995;6:561-562.

Boffetta P. Molecular Epidemiology. J Int Med 2000;248:447-454.

 

April 2, 2003

"Reliability Studies for Biological Marker Data"

Session Leader: Emily White

Readings:  

White E. Effects of biomarker measurement error on epidemiologic studies. In: Tonolio P, Boffetta P, Shuker DEG, Rothman N, Hulka B, Pearce N. Application of Biomarkers in Cancer Epidemiology. IARC Scientific Publications. No. 142., Lyon, 1997.

Begin Assignment #1

 

April 7, 2003

"Reliability Studies for Biological Marker Data" (continued from April 2 session)

Assignment #1 Due and Discussed

 

April 9, 2003

"Overview of Molecular Biology"

Session Leader: Debbie Nickerson

Readings:

 

Schulte PA, Chapter 2. (Hurst RE, Rao JY. Molecular Biology in Epidemiology. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

Lorentz CP, Wieben ED, Tefferi A, Whitement DAH, Dewald GW. Primer on medical genomics part I: history of genetics and sequencing of the human genome. Mayo Clin Proc 2002;77:773-782.

Tefferi A, Wieben ED, Dewald GW, Whietmean DAH, Bernard ME, Spelsberg TC. Primer on medical genomics part II: background principles and methods in molecular genetics. Mayo Clin Proc 2002;77:785-808.

Tefferi A, Bolander ME, Ansell SM, Wieben ED, Spelsberg TC. Primer on medical genomics part III: microarray experiments and data analysis. Mayo Clin Proc 2002;77:927-940.

Pardanani A, Wieben ED, Spelsberg TC, Tefferi A. Primer on medical genomics part IV: expression proteomics. Mayo Clin Proc 2002;77:1185-1196.

 

April 14, 2003

"Overview of Molecular Biology" (continued from April 9 session)

 

 

April 16, 2003

"Transitional Studies"

Session Leader: Steve Schwartz

Readings:   

Howie AF et al.. Measurement of glutathione S-transferase P1 isozyme in plasma: a possible marker for adenocarcinoma of the lung. Clin Chem 1990; 36:453-456.

Schulte PA. Chapter 6 (pp 161-166 only) (Schulte PA, Rothman N, Schottenfeld D. Design Considerations in Molecular Epidemiology. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

Schulte PA. Chapter 3 (pp 92-104 only) (Schulte PA, Perera FP. Validation. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

 Article Discussion (Howie et al).

 

 

April 21, 2003

"Transitional Studies" (continued from April 16 session)

 

April 23, 2003

"Study Design and Implementation"

Session Leader: Steve Schwartz

Readings:    

 

Potter JD. Logistics and design issues in the use of biological samples in observational epidemiology. In: Tonolio P, Boffetta P, Shuker DEG, Rothman N, Hulka B, Pearce N. Application of Biomarkers in Cancer Epidemiology. IARC Scientific Publications. No. 142., Lyon, 1997.

Landi MT, Caparaso N. Sample collection, processing, and storage. In: Tonolio P, Boffetta P, Shuker DEG, Rothman N, Hulka B, Pearce N. Application of Biomarkers in Cancer Epidemiology. IARC Scientific Publications. No. 142., Lyon, 1997.

Schulte PA. Chapter 6 (pp 159-161, 166-198 only) (Schulte PA, Rothman N, Schottenfeld D. Design Considerations in Molecular Epidemiology. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

Schulte PA. Chapter 8 (Winn DM, Gunter EW. Biologic Specimen Banks: A Resource for Molecular Epidemiologic Studies. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

Vineis P, McMichael AJ. Bias and confounding in molecular epidemiological studies: special considerations. Carcinogenesis 1998 Dec;19(12):2063-7.

Sham P, Bader JS, Craig I, O'Donovan M, Owen M. DNA Pooling: a tool for large-scale association studies. Nat Rev Genet 2002 Nov;3(11):862-71.

 

 

April 28, 2003

"Study Design and Implementation" (continued from April 23 session)

 

 

April 30, 2003

"Laboratory Quality Control"

Session Leader: Jeannette Bigler

Readings:   

Aitio A, Apostoli P. Quality assurance in biomarker measurement. Toxicol Lett 1995 May;77:195-204

Schulte PA. Chapter 4 (Vineis P, Schulte PA, Vogt RF Jr. Technical Variability in Laboratory Data. In: PA Schulte, FP Perera. Molecular Epidemiology. Principles and Practice, Academic Press, Inc. New York, 1993.)

 

 

May 5, 2003

"Application: Cardiovascular Disease"

Session Leader: Melissa Austin

Readings: 

Austin MA, et al. Prospective study of small LDLs as a risk factor non-insulin dependent diabetes mellitus in elderly men and women. Circulation 1995;92:1770-1778.

Kamigaki AS, Siscovick DS, Schwartz SM†, Psaty BM, Edwards KL, Raghunathan TE, Austin MA. Low-density lipoprotein particle size and risk of early-onset myocardial infarction in women. Am J Epidemiol 2001;153:939-945.

 

May 7, 2003

"Biomarker Research In Silico"

Session Leaders: Neli Ulrich and Rachel Sparks

Readings: 

 

Ulrich CM, Bigler J, Velicer CM, Greene EA, Farin FM, Potter JD. Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol. Biomarkers Prev. 2000;12:1381-86.

Ng PC, Henikoff S. Accounting for human polymorphisms predicted to affect protein function. Genome Res 2002 Mar;12(3):436-46

Ng PC, Henikoff S. Predicting deleterious amino acid substitutions. Genome Res 2001 May;11(5):863-74.

Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 2001 Jan 1;29(1):308-11.  

 

 

May 12, 2003

"Application: Nutritional Biomarkers and Disease Mechanisms"

Session Leader: Johanna Lampe

Readings: 

 

Lampe JW, Peterson S.  Brassica, biotransformation, and cancer risk:  genetic polymorphisms alter the preventive effects of cruciferous vegetables. J. Nutr., 132:2991-2994, 2002.

London SJ, Yuan JM, Chung FL, Gao YT, Coetzee GA, Ross RK, Yu MC. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk:  a prospective study of men in Shanghai, China. Lancet 2000;356:724-729.

Setchell, KD, Brown, NM, Lydeking-Olsen, E.  THe clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 132:3577-84, 2002.

Akaza H, Miyanaga N, Takashima N, Naito S, Hirao Y, Tsukamoto T, Mori M. Is daidzein non-metabolizer a high risk for prostate cancer? A case-controlled study of serum soybean isoflavone concentration. Jpn J Clin Oncol 2002;32:296-300.

 

May 14, 2003

"Application: Biomarkers and Early Detection of Cancer"  

Session Leader: Martin McIntosh

Readings:

McIntosh MW, Pepe MS. Combining several screening tests: optimality of the risk score. Biometrics 2202; 58:657-664.

Zhang Z, Bamhill SD, Zhang H, Xu F, Yu Y, Jacobs I, Woolas RP, Berchuck A, Madyastha KR, Bast Jr RC. Combination of Multiple Serum Markers Using an Artificial Neural Network to Improve Specificity in Discriminating Malignant from Benign Pelvic Masses. Gynecol Oncol 1999;73, 56–61. 

Begin Assignment #3

 

May 19, 2003

"Application: Cervical Carcinoma"

Session Leader: Steve Schwartz

Reading: 

zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002 May;2(5):342-50.

 

 

May 21, 2003

"Study of Protein Expression in Tissue"

Session Leader: Peggy Porter

Reading: 

Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ, Daling JR, Roberts JM. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 1997;3:222-5.

 

 

May 26, 2003

No Class! Memorial Day Holiday

 

May 28, 2003

"Ethical Issues in Biomarker Studies"

Session Leaders: Anna Mastroianni & Steve Schwartz

 

Readings: 

 

Clayton EW et al. Informed consent for genetic research in stored tissue samples. JAMA 1995;274:1786-1792.

Weir RF, Horton JR. DNA banking and informed consent – Part 1. IRB 1995;17:1-8.

Weir RF, Horton JR. DNA banking and informed consent – Part 2. IRB 1995;17:1-4.

ASHG. Statement on informed consent for genetic research. Am J Human Genet. 1996;59:471-474.

Holtzman NA, Andrews LB. Ethical and legal issues in genetic epidemiology.  Epidemiol Rev. 1997;19:163-173.

National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects Research. National Institutes of Health, 1979.

Beskow LM, Burke W, Merz JF, Barr PA, Terry S, Penchaszadeh VB, Gostin LO, Gwinn M, Khoury MJ. Informed consent for population-based research involving genetics.
JAMA 2001 Nov 14;286(18):2315-21.

 

 

June 2, 2003

"Student Presentations"

 

June 4, 2003

"Student Presentations"

 

June 9, 2003

"Student Presentations"