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Lecture
Material and Notes
Week 1, Lecture 1: Overview
and goals
Martin Kushmerick
Lecture theme and outline:
This course is designed to help your transition into graduate school and
in particular to bioengineering. Bioengineering is preeminently an integrating
discipline, at the intersections of virtually all disciplines in biology
and engineering.
The major content, elements
and principles to be taught are:
- Protein-protein interactions;
- Machines coupling a thermodynamic
driving force with a mechanical, osmotic and electrical work;
- Exploring functions at scales
differing by 9 orders of magnitude, from nanometers to meters;
- Metabolic machines as computing
and signaling machines; metabolic processes as chemical networks driving
exergonic biological functions;
- Membrane separate functional
domains and channels are inter-domain communication machines;
- Control of components and
systems and regulation of function.
This course uses muscle as
the physiological material to develop these themes.
Suggested reading:
- Molecular
Biology of the Cell P17 - 24 Intracellular organelles and structures
- general background information all students should know.
- Molecular
Biology of the Cell Scan P847-858 (return to this section for Lecture
4 and Lecture 5)
- T. A. McMahon, Muscles,
Reflexes and Locomotion, Princeton Univ Press, 1984 (out of print) Ch
1 and 2 (copies to be distributed)
- C.R. Bagshaw, Muscle Contraction,
1993 (second edition) Ch 2 (copies to be distributed)
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