Osteoclast inhibitors

RANK-Ligand inhibitors

These primarily inhibit the formation of osteoclasts from pre-osteoclasts. Denosumab is currently in phase 3 testing, and there is a separate page for these drugs.

Integrin and cathepsin K inhibitors


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Horton MA. Upregulation of osteoclast alpha2beta1 integrin compensates for lack of alphavbeta3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia. Br J Haematol 2003;122(6):950-7.

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McClung MR. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 2006;354(8):821-31.

McHugh KP. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 2000;105(4):433-40.

Murphy MG. Effect of L-000845704, an alphaVbeta3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab 2005;90(4):2022-8.

Yarali N. Osteopetrosis and Glanzmann's thrombasthenia in a child. Ann Hematol 2003;82(4):254-6.

Updated 5/11/06