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ENVH 535, Fall Quarter
Inhalation Toxicology
 
Research Articles
 
OZONE REFERENCES
BIOMARKER:  
  • Arsalane, K., F. Broeckaert, B. Knoops, A. Clippe, J. P. Buchet, and A. Bernard. Increased serum and urinary concentrations of lung Clara cell protein in rats acutely exposed to ozone. Toxicol Appl Pharmacol 159: 169-74, 1999 [URL]

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  • Broeckaert, F., K. Arsalane, C. Hermans, E. Bergamaschi, A. Brustolin, A. Mutti, and A. Bernard. Serum Clara Cell Protein: A Sensitive Biomarker of Increased Lung Epithelium Permeability Caused by Ambient Ozone. Environ Health Perspect 108: 533-537, 2000.

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  • Frampton, M. W., W. A. Pryor, R. Cueto, C. Cox, P. E. Morrow, and M. J. Utell. Ozone exposure increases aldehydes in epithelial lining fluid in human lung. Am J Respir Crit Care Med 159: 1134-7, 1999. [URL]

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  • Liu, L., J. A. Leech, R. B. Urch, R. Poon, B. Zimmerman, J. M. Kubay, and F. S. Siverman. A comparison of biomarkers of ozone exposure in human plasma, nasal lavage, and sputum. Inhal Toxicol 11: 657-74, 1999.

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CO-FACTOR:  
  • Adamson, I. Y., R. Vincent, and S. G. Bjarnason. Cell injury and interstitial inflammation in rat lung after inhalation of ozone and urban particulates. Am J Respir Cell Mol Biol 20: 1067-72, 1999. [URL]

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  • Cho, H. Y., J. A. Hotchkiss, C. B. Bennett, and J. R. Harkema. Effects of pre-existing rhinitis on ozone-induce mucous cell metaplasia in rat nasal epithelium. Toxicol Applied Pharmacol 158: 92-102, 1999.

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  • Nielsen, G. D., K. S. Hougaard, S. T. Larsen, M. Hammer, P. Wolkoff, P. A. Clausen, C. K. Wilkins, and Y. Alarie. Acute airway effects of formaldehyde and ozone in BALB/c mice. Human Exp Toxicol 18: 400-9, 1999.

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  • Wiester, M. J., D. W. Winsett, J. H. Richards, M. C. Jackson, K. M. Crissman, and D. L. Costa. Ozone Adaptation in Mice and Its Association with Ascorbic Acid in the Lung. Inhal Toxicol 12: 577-590, 2000.

 

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GENETIC SUSCEPTIBILITY:
  • Prows, D. R., M. J. Daly, h. G. Shertzer, and G. D. Leikauf. Ozone-induce acute lung injury: genetic analysis of F2 mice generated from A/J and C57BL/J strains. Am J Physiol 277: L372-80, 1999.

 

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INJURY & INFLAMMATION:  
  • Bhalla, D. K., and S. K. Gupta. Lung injury, inflammation, and inflammatory stimuli in rats exposed to ozone. J Toxicol Environ Health, Part A 59: 211-28, 2000.

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  • Bhalla, D. K., s. K. Gupta, and P. G. Reinhart. Alteration of epithelial integrity, alkaline phosphatase activity, and fibronectin expression in lungs of rats exposed to ozone. J Toxicol EnviroN Health, Part A 56: 329-43, 1999.

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  • Cho, H. Y., J. A. Hotchkiss, and J. R. Harkema. Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats. Toxicol Sci 51: 135-45, 1999.

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  • Hoffer, E., Y. Baum, A. Tabak, and C. Frevert. Adhesion molecules of blood polymorphonuclear leukocytes and alveolar macrophages in rats: modulation by exposure to ozone. Hum Exp Toxicol 18: 547-51, 1999.

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  • Postlethwait, E. M., J. P. Joad, D. M. Hyde, E. S. Schelegle, J. M. Bric, A. J. Weir, L. F. Putney, V. J. Wong, L. W. Velsor, and C. G. Plopper. Three-dimensional mapping of ozone-induced acute cytotoxicity in tracheobronchial airways of isolated perfused rat lung. Am J Respir Cell Mol Biol 22: 191-9, 2000. [URL]

 

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MUTAGEN/CARCINOGEN:  
  • Haney, J. T., T. H. Connor, and L. Li. Detection of Ozone-Induced DNA Single Strand Breaks in Murine Bronchoalveolar Lavage Cells Acutely Exposed In Vivo. Inhal Toxicol 11: 331-341, 1999.

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  • Witschi, H., I. Espiritu, K. E. Pinkerton, K. Murphy, and R. R. Maronpot. Ozone carcinogenesis revisited. Toxicol Sci 52: 162-7, 1999.

 

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SPECIES/STRAIN DIFFERENCES:  
  • Depuydt, P., G. F. Joos, and R. A. Pauwels. Ambient ozone concentrations induce airway hyperresponsiveness in some rat strains. Eur Respir J 14: 125-31, 1999.

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  • Dormans, J. A. M. A., v. L. Bree, A. J. F. Boere, M. Marra, and P. J. A. Rombout. Interspecies Differences in Time Course of Pulmonary Toxicity Following Repeated Exposure to Ozone. Inhal Toxicol 11: 309-329, 1999.

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  • Dye, J. A., M. C. Madden, J. H. Richards, J. R. Lehmann, R. B. Devlin, and D. L. Costa. Ozone Effects on Airway Responsiveness, Lung Injury, and Inflammation. Comparative Rat Strain and In Vivo/In Vitro Investigations. Inhal Toxicol 11: 1015-1040, 1999.

 

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STANDARD SETTING:  
  • Lippmann, M., and R. B. Schlesinger. Toxicological bases for the setting of health-related air pollution standards. Annu Rev Public Health 21: 309-33, 2000.

 

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NO2 REFERENCES
  • Barth PJ, Muller B. Effects of nitrogen dioxide exposure on Clara cell proliferation and morphology. Pathol Res Pract 1999; 195:487-93.

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  • Bayram H, Devalia J, Khair O, Abdelaziz M, Sapsford R, Czarlewski W, Campbell A, Bousquet J, Davies R. Effect of loratadine on nitrogen dioxide-induced changes in electrical resistance and release of inflammatory mediators from cultured human bronchial epithelial cells. J Allergy Clin Immunol 1999; 104(1):93-9.

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  • Becker S, Soukup JM. Effect of nitrogen dioxide on respiratory viral infection in airway epithelial cells. Environ Res 1999; 81(2):159-66.

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  • Bermudez E, Ferng SF, Castro CE, Mustafa MG. DNA strand breaks caused by exposure to ozone and nitrogen dioxide. Environ Res 1999; 81(1):72-80. [URL]

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  • Johnston CJ, Reed CK, Avissar NE, Gelein R, Finkelstein JN. Antioxidant and Inflammatory Response After Acute Nitrogen Dioxide and Ozone Exposures in C57Bl/6 Mice. Inhal Toxicol 2000; 12(3):187-203.

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  • Martin LD, Krunkosky TM, Voynow JA, Adler KB. The Role of Reactive Oxygen and Nitrogen Species in Airway Epithelial Gene Expression. Environmental Health Perspectives 1998; 106(Supplement 5):1197-1203.

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  • Schierhorn K, Zhang M, Matthias C, Kunkel G. Influence of ozone and nitrogen dioxide on histamine and interleukin formation in a human nasal mucosa culture system. Am J Respir Cell Mol Biol 1999; 20(5):1013-9. [URL]

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  • Weller BL, Witschi H, Pinkerton KE. Quantitation and localization of pulmonary manganese superoxide dismutase and tumor necrosis factor a following exposure to ozone and nitrogen dioxide. Toxicol Sci 2000; 54(2):452-61.

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  • Zhu S, Manuel M, Tanaka S, Nonghoon C, Kagan E, Matalon S. Contribution of Reactive Oxygen and Nitrogen Species to Particulate-Induced Lung Injury. Environ Health Persp 1998; 106(Supplement 5):1157-1163.

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SO2 REFERENCES
  • Clarke RW, Antonini JM, Hemenway DR, Frank R, Kleeberger SR, Jakab GJ. Inhaled Particle-Bound Sulfate: Effects on Pulmonary Inflammatory Responses and Alveolar Macrophage Function. Inhal Toxicol 2000; 12(3):169-186.

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  • Kodavanti UP, Jackson MC, Ledbetter AD, Starcher BC, Evansky PA, Harewood A, Winsett DW, Costa DL. The combination of elastase and sulfur dioxide exposure causes COPD-like lesions in the rat. Chest 2000; 117:299S-302S.

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  • Ohtsuka Y, Clarke RW, Mitzner W, Brunson K, Jakab GJ, Kleeberger SR. Interstrain variation in murine susceptibility to inhaled acid-coated particles. Am J Physiol Lung Cell Mol Physiol 2000; 278(3):L469-76.

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  • Rogers JF, Thompson SJ, Addy CL, McKeown RE, Cowen DJ, Decoufle P. Association of very low birth weight with exposures to environmental sulfur dioxide and total suspended particulates. Am J Epidemiol 2000; 151(6):602-13.

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  • Takenaka S, Godleski JJ, Heini A, Karg E, Kreyling WG, Ritter B, Schulz H, Ziesenis A, Heyder J. Health Effects of Sulfur-Related Environmental Air Pollution. V. Lung Structure. Inhalation Toxicology 1999; 11:439-454.

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SiO2 REFERENCES
  • Adamis, Z., E. Tatrai, K. Honma, E. Six, and G. Ungvary. In vitro and in vivo tests for determination of the pathology of quartz, diatomaceous earth, mordenite and clinoptilolite. Ann Occup Hyg 44: 67-74, 2000.

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  • Barrett, E. G., C. Johnston, G. Oberdorster, and J. N. Finkelstein. Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure. Toxicol Appl Pharmacol 158: 211-20, 1999. [URL] 

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  • Barrett, E. G., C. Johnston, G. Oberdorster, and J. N. Finkelstein. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress. Am J Physiol 276: L979-88, 1999.

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  • Davis, G. S., L. M. Pfeiffer, and D. R. Hemenway. Expansion of interferon-gamma-producing lung lymphocytes in mouse silicosis. Am J Respir Cell Mol Biol 20: 813-24, 1999. [URL] 

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  • Finkelstein, M. M. Silica, silicosis, and lung cancer: a risk assessment. Am J Ind Med 38: 8-18, 2000.

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  • Huaux, F., M. Arras, A. Vink, J. C. Renauld, and D. Lison. Soluble tumor necrosis factor (TNF) receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice. Am J Respir Cell Mol Biol 21: 137-45, 1999. [URL] 

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  • Huaux, F., C. Lardot, M. Arras, M. Delos, M. C. Many, J. P. Coutelier, J. P. Buchet, J. C. Renauld, and D. Lison. Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations. Am J Respir Cell Mol Biol 20: 561-72, 1999.[URL] 

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  • Johnston, C. J., K. E. Driscoll, J. N. Finkelstein, R. Baggs, M. A. O'Reilly, J. Carter, R. Gelein, and G. Oberdorster. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci 56: 405-13, 2000.

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  • Lay, J. C., W. D. Bennett, A. J. Ghio, P. A. Bromberg, D. L. Costa, C. S. Kim, H. S. Koren, and R. B. Devlin. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. Am J Respir Cell Mol Biol 20: 631-42, 1999. [URL] 

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  • van Maanen, J. M., P. J. Borm, A. Knaapen, M. van Herwijnen, P. A. Schilderman, K. R. Smith, A. E. Aust, M. Tomatis, and B. Fubini. In vitro effects of coal fly ashes: hydroxyl radical generation, iron release, and DNA damage and toxicity in rat lung epithelial cells. Inhal Toxicol 11: 1123-1141, 1999.

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  • Zhang, Z., H. M. Shen, Q. F. Zhang, and C. N. Ong. Involvement of oxidative stress in crystalline silica-induced cytotoxicity and genotoxicity in rat alveolar macrophages. Environ Res 82: 245-52, 2000.

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  • Zielinski, H., I. S. Mudway, K. A. Berube, S. Murphy, R. Richards, and F. J. Kelly. Modeling the interactions of particulates with epithelial lining fluid antioxidants. Am J Physiol 277: L719-26, 1999.[URL] 

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IN VITRO
  • Frampton, M. W., A. J. Ghio, J. M. Samet, J. L. Carson, J. D. Carter, and R. B. Devlin. Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells. Am J Physiol 277: L960-L967, 1999.[URL] 
  • Hashimoto, S., Y. Gon, I. Takeshita, K. Matsumoto, I. Jibiki, H. Takizawa, S. Kudoh, and T. Horie. Diesel Exhaust Particles Activate p38 MAP Kinase to Produce Interleukin 8 and RANTES by Human Bronchial Epithelial Cells and N-Acetylcysteine Attenuates p38 MAP Kinase Activation. Am J Respir Crit Care Med 161: 280-285, 2000.[URL] 

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  • Oettinger, R., K. Drumm, M. Knorst, P. Krinyak, R. Smolarski, and K. Kienast. Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-kappa B p50/p105 mRNA. Lung 177: 343-54, 1999. [URL] 

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  • Wu, W., L. M. Graves, I. Jaspers, R. B. Devlin, W. Reed, and J. M. Samet. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals. Am J Physiol 277: L924-L931, 1999.[URL]

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INVIVO
  • Gavett, S. H., S. L. Madison, M. A. Stevens, and D. L. Costa. Residual Oil Fly Ash Amplifies Allergic Cytokines, Airway Responsiveness, and Inflammation in Mice. Am J Respir Crit Care Med 160: 1897-1904, 1999. [URL] 
  • Longphre, M., D. Li, J. Li, E. Matovinovic, M. Gallup, J. M. Samet, and C. B. Basbaum. Lung mucin production is stimulated by the air pollutant residual oil fly ash. Toxicol Appl Pharmacol 162: 86-92, 2000. [URL] 
  • Nemmar, A., A. Delaunois, B. Nemery, C. Dessy-Doiz, J. F. Beckers, J. Sulon, and P. Gustin. Inflammatory Effect of Intratracheal Instillation of Ultrafine Particles in the Rabbit: Role of C-fiber and Mast Cells. Toxicol Appl Pharmacol 160: 250-261, 1999. [URL]
  • Nikula, K. J. Rat lung tumors induced by exposure to selected poorly soluble nonfibrous particles. Inhalation Toxicology 12: 97-119, 2000. [URL]  

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Contact the instructor at: dluchtel@u.washington.edu