Assignments Week 9

May 28 – Gene/environment interactions 
Susan Searles Nielsen

Readings:

• Checkoway H, Bhatti P, De Roos AJ. Epidemiologic approaches.  IN: Costa LG, Eaton DL (eds.) Fundamentals of Ecogenetics. John Wiley & Sons, Hoboken, NJ, 2006; pp51-71.
• Cantor K, Villanueva CM, Silverman DT, et al.  Polymorphisms in GSTT1, GSTZ1, and CYP2E1, Disinfection Byproducts, and Risk of Bladder Cancer in Spain.  Environ Health Perspect 2010;118:1545-50.
• Wenten M,Gauderman WJ, Berhane K, Lin PC, Peters J, Gilliland FD. Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. Am J Epidemiol 2009;170:1494-1501.

May 30 – Special applications of occupational/environmental epidemiology
Harvey Checkoway

Readings:

• Lenters V, Basinas T, Beane Freeman L, et al. Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers. Cancer Causes & Control 2010;21:523-55.
• Park R, Rice F, Stayner L, et al. Exposure to crystalline silica, silicosis, and lung disease other than cancer in diatomaceous earth industry workers: a quantitative risk assessment. Occup Environ Med 2002;59:36-43.
• Hill AB. The environment and disease: association or causation?  Proc Roy Soc Med 1965;58:295-300.