Langerhans cells week 6

Langerhans cells appear in the epidermis

Cells having a clear cytoplasm and lacking desmosomal attachments to keratinocytes appear in the epidermis during the 6th week of gestation. Some of these cells may be melanocytes, but some of them label with the characteristic markers of Langerhans cells, cytoplasmic Mg++ dependent ATPase, and HLA-DR. These cells are small and truncated compared to Langerhans cells later in development.

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