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Course Information
Credit Hours: Three quarter credits
Format: Three
lectures per week and one optional conference per
week
Faculty:
- Dr. Kent Kunze (Course Coordinator)
- Dr. Bill Atkins
- Dr. Dave Porubek
- Dr. Allan Rettie
Student Learning Objectives and Competencies:
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To understand the physicochemical properties of medicinal agents, such as chemical bonding,
ionization, lipophilicity and stereochemistry, so that the student is able to relate this information
to absorption, distribution, receptor interactions and excretion.
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To know the most important pathways of drug metabolism and the enzymes involved, so that the
student is able to relate this information to drug action, drug-drug interactions, and to some
drug toxicities.
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To know the major kinds of cancers and some predisposing factors, and to know the phases of
carcinogenesis, so that the student can logically analyze information about cancer found in
the public domain, and be able to communicate with others about the basis for various kinds
of cancers and their treatments.
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To recognize the structural features of the most widely used anti-cancer agents, their major
therapeutic uses and dose-limiting toxicities, and their mechanisms of action, so that the
student is able to relate this information to the development and use of combination chemotherapy
regimens in the treatment of cancers.
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To know the difference between the RDA and USRDA vitamin and mineral intake values thought to be
required for optimum human health, be able to identify consequences of suboptimal and supraoptimal
vitamin and mineral intake, and to know mechanisms of metabolic reactions in which vitamins and
minerals participate. With this knowledge base, the student should be able to discuss with
patients rational therapeutic uses of vitamins and minerals, their dietary sources, and when
and which supplements might be needed.
Grading Policy:
Grades are based on performance on two 100-point one-hour
exams and one 100-point final exam. An overall 75%
achievement will translate to a 2.6 GPA and 90% or
above to a 4.0. Anything below 55% will translate
to a 0.0.
Recommended Course Text (not required): T.L.
Lemke, et al., Foye's Principles
of Medicinal Chemistry 7th Edition, 2013; or 6th Edition,
2008
Course Website:
http://courses.washington.edu/medch562/
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