Conflict of interest
Conflict of interest statement from an ORI training module: Conflict of interest (COI) issues highlight the potential for authors to compromise research integrity and bias how research is conducted, from deciding what research questions to pursue, to determine how data should be analyzed and interpreted.
- University of Minnesota Ethics Curriculum on Conflict of Interest
- NIH Links: General conflict of interest information and Conflict of Interest Resources
- IOM Report Brief: Conflict of Interest in Medical Research, Education, and Practice. April 2009
- AAMC publication Protecting Patients, Preserving Integrity, Advancing Health: Accelerating the Implementation of COI Policies in Human Subjects Research, February 2008
- JAMA 2006 Conflict of interest policy statement update with a definition of COI
Journal editorials
- DeAngelis & Fontanarosa 2008 JAMA editorial on the adverse effects of industry influcence on research following up on the apparent misrepresentation of Vioxx results and proposing 11 changes to the analysis and reporting of clinical trials.
- DeAngelis & Fontanarosa 2009 JAMA editorial on journals, undisclosed conflcts, and the press
- DeAngelis 2000 JAMA editorial on conflict of interest and the public trust with discussion of the Kahn et al Remune study
- Korn 2000 JAMA editorial on financial conflicts of interest in academic medicine, also in the same issue as the Kahn et al Remune study
- Psaty 2009 JAMA editorial on conflict of interest, disclosure, and trial reports
- 2003 JAMA editorial by Dana & Lowenstein discussing gifts to physicians. They present a social science perspective and discuss of the concept of "self-serving bias"
- Allison's 2009 Science editorial "The antidote to bias in research" discusses the movement towards better disclosure of COI and argues more transparency and public availability of data is also needed. Here is Wray's reply arguing it is essential to disclose financial COIs.
Research papers with a conflict of interest focus
- Psaty et al 2004 JAMA paper entitled Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis
- Turner et al 2008 NEJM paper entitled Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy and letters to the editor
REFERENCES
Brennan T; Rothman D; Blank L.; Health Industry Practices That Create Conflicts of Interest: A policy Proposal for Academic Medical Centers; JAMA 2006 May; 295(4):429-433
Goldblum O.; Franzblau M.; Academic Medical Centers and Conflicts of Interest; JAMA 2006 May;295(24):2844-2846
Carlat D.; Dr Drug Rep; The New York Times 2007 Nov.
Psaty B; Industry, Medicine, and Conflict of Interest: The View of a Physician-Epidemiologist; CHRU 2008
DeAngelis C.; Conflict of Interest and the Public Trust; JAMA 2009 Apr; 284(17): 2237-2238
Deyo R; Psaty B; Simon G; Wagner E.; Omenn G.; The Messenger under Attack – Intimidation of Researchers by Special-Interest Groups, N Engl J Med 1997 April;336(16):1176-1180
Deyo R.; Bruce Psaty and the risks of calcium channel blockers; Wal.Saf.Health Care 2002 Jul; 11:294-296
Elliott C.; The Drug Pusher, As America turns its health-care system over to the market, pharmaceutical reps are wielding more and more influence- and the line between them and doctors is beginning to blur; Atlantic Monlthy 2006 Apr; 2-13
Fontanarosa P.; Rennie D.; DeAnglis C.; Postmarketing Surveillance-Lack of Vigilance, Lack of Trust; JAMA 2004 Dec:209(21):2647-2650
Lo B.; Baldwin W.; Bellini L.; Bero L.; Campbell E.;Childress J.; Corr P.; Dorman T.;Grady D.;Jost T.; Kelch R.;Krughoff R.; Loewenstein G.; Perlmutter J.;Powe N.; Thompson D.; Williams D.; Conflict of Interest in Medical Research, Education, and Practice; IOM 2009 April; 1-4
Korn D.; Conflicts of Interest in Biomedical Research; JAMA 2000 April; 284(17):2234-2237
DeAngelis C.; Fontanarosa P.; Conflict Over Conflicts of Interest, JAMA 2009 Mar:E1-E3
Psaty B.; Furberg C.; Ray W.; Weiss N.; Potential for Conflict of Interest in the Evaluation of Suspected Adverse Drug Reactions, Use of Cerivastatin and Risk of Rhabdomyolysis; JAMA 2004 Dec; 29(21):2622-2631
Psaty. B; Conflict of Interest, Disclosure, and Trial Reports; JAMA 2009 April; 301(14):1477-1479
Sah S.; Loewenstein G.; Effect of Reminders of Personal Sacrifice and Suggested Rationalizations of Residents’ Self-Reported Willingness to Accept Gifts: A Randomized Trial, JAMA 2010 Sep; 304(11):1204-1211
Turner E.; Matthews A.; Linardatos E.; Tell R.; Rosenthal R.; Special Article ,Selective Publication of Antidepressant Trials and Its Influence of Apparent Efficacy; N Engl J Med 2008 Jan;358:252-260
Turner E.; Tell R.; Selective Publication of Antidepressant Trials; N Engl J Med 2008 May;328(20): 2181-2182