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Class Schedule contents:

Week 1

Week 2

Week 3

Week 4

Week 5

Week 6

Week 7

Week 8

Week 9

Week 10

Week 11

 

BIOEN 485/585, Spring 2014
Computational Bioengineering

NOTE: this is a draft schedule.

the current schedule will be kept on the Canvas site.

 

Draft Weekly Class Schedule

  • Once the quarter has started, assignments will be uploaded to the Canvas site, not here.
week Monday Lecture Wednesday Lecture Lab
1

March 31: lecture 1: Introduction to Modeling

  • Introduction to modeling
  • Verification 1: model building
  • Building biochemical reaction models
  • Post final project

April 2 , lecture 2: ODE model building

  • Model Building Tools: systems approach to linear electrical, mechanical, chemical and fluidic systems (Khoo chapter 2)

Lab 1:

 

2

April 7 , lecture 3: linear ODE solutions. (posted on canvas site)

  • Transfer function representations
  • Stability and steady state analysis.
  • Verification 2: solutions

April 9 , lecture 4 linear ODE systems analysis. (posted on canvas site)

  • State space representation
  • Bifurcation and sensitivity analysis
  • Lab 1 due
  • Article Discussion 1: Maitani & Verification

Lab 2:

3

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April 14 , lecture 5: Nonlinear Systems Analysis

  • Nullclines and equilibrium points
  • Jacobian: Linearization of nonlinear systems.
  • Validation
  • Answer questions about final project assignment.

April 16 , lecture 6 Nondimensionalization

  • Bifurcation analysis in nonlinear systems
  • Nondimensionalization
  • Lab 2 due
  • Article Discussion 2: Gardner & Validation

Lab 3:

  • Nonlinear ODE Systems Analysis
4 April 21 , lecture 7 PDE model building (transport models)
  • gradient, divergence, laplacian, flux
  • boundary conditions
  • steady state solutions and characteristic times
  • diffusion example

April 23 , lecture 8 PDE solutions and analysis

  • convection and reaction
  • numerical solution methods
  • Lab 3 due
  • Discuss sample proposal (no article discussion due)

 

Lab 4:

  • PDE Simulations
  • optional: Introduction to COMSOL
5

April 28, lecture 9 Nondimensionalization for PDEs

  • nondimensionalization
  • Discuss project ideas

April 30, lecture 10 Transport Examples

  • Lab 4 due
  • Article discussion 3
  • Project proposals due on Friday May 2

Lab 5:

  • PDE Analysis

6

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May 5, lecture 11. Stochastic Simulations Overview

  • Review of probability distributions and statistics
  • The MathWorld is a good reference for statistics.
  • Discuss Project Proposals

May 7 , lecture 12. Brownian Dynamics (Diffusion; Langevan Equation, Wiener Process)

  • Lab 5 due
  • recommended reading: Higham 2001, pp. 525–533 ONLY.
  • Article Discussion: Nitta

Lab 6

  • SDEs: Brownian Motion
7

May 12 , lecture 13. Stochastic chemical reaction equations

  • Gillespie Exact, Tau-leap method, Chemical Langevin Equation
  • recommended reading: Higham 2007
  • Final Project Teams Meet

May 14, lecture 14 Examples of Stochastic Reaction Equations

 

 

  • lab 6 due
  • Article Discussion: Artyomov

 

Lab 7

  • SDEs: Chemical Reactions
8

May 19, lecture 15. System Identification I

  • Parameter estimation
  • least squares
  • measurement error and weighting schemes
  • Milestone 1: Literature

 

May 21 , lecture 16. System Identification II

  • examples
  • Lab 7 due

Lab 8

  • System Identification

9

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May 26: MEMORIAL DAY

May 28, lecture 17. Validation vs Value added in Thomas Lab Modeling

  • Lab 8 due
  • Milestone 2: Verification and Validation

Lab 9:

  • Milestone 3: Methods
10

June 2, Lecture 19. No Class!!

  • milestone 4 moved to Wednesday.

June 4, Review

  • Review of course
  • Milestone 4: Value

 

Lab 10

  • Milestone 5
  • course evaluations
finals week
  • Final project due: Tuesday June 10, 5 pm

Oral project presentations: Wednesday, June 11, 2014,830-1020, BAG 261

enjoy the summer!

 

 

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 Last Updated:
June 1, 2014