Links to other pages in this course website:

HOME PAGE

grade book

collect-it drop box

Class Schedule contents:

Week 1

Week 2

Week 3

Week 4

Week 5

Week 6

Week 7

Week 8

Week 9

Week 10

Week 11

 

BIOEN 485, Autumn 2009
Computational Bioengineering

 

Class Schedule

  • New material will be added each week, particularly as lecture notes, assignments, and solutions are added to the web site.
week Tuesday Lecture Thursday Lecture Lab
1

 

Sept 30: lecture 1: Introduction to Modeling (compartmental models, checking solutions, numerical solutions to higher order ODEs)

  • discussion issues 1: how do you know if an analytic or numerical solution is mathematically correct?
  • Recommended : Khoo, Chapter 1

Oct 1/2 Lab 1:

(lab 1 posted here openly so everyone can access while registrations is finalized)

Introduction to Modeling with MATLAB

2

Oct 5, lecture 2: Linear Systems Model Building (mechanical, fluid, chemical, electrical systems and the systems approach.

Oct 7, lecture 3: Solutions to Linear Systems. (superposition, state-space, Laplace transforms) (Deepak Chandran)
  • discussion issues 2: level of certainty.
  • lab 1 due at 10:00 am via CollectIt

Oct 7/8 Lab 2:

Linear Model building

3

<-- RETURN TO TOP

Oct 12, lecture 4 Steady State Analysis

  • recommended: Khoo, Chapter 4.1 to 4.6, and 6.1 and 6.2,

 

Oct 14, lecture 5 Time Domain Analysis, Feedback and Stability

  • Discussion 3: Impact of Models.
  • Lab 2 due

 

Oct 14/15 Lab 3:

Linear Systems Analysis

4 Oct 19, lecture 6 Nonlinear Systems Analysis I(Jacobian and Stability, Phase-plane response and nullclines)
  • Recommended: Khoo, Chapter 9.1 to 9.3
 
  • Article Discussion 3 due via CollectIt at 10:00: Gardner et al and model impacts

Oct 21, lecture 7 Nonlinear Analysis cont. (Nondimensionalization, Bifurcation Theory, Sensitivity Analysis.)

  • P.G. Drazin, "Nonlinear Systems", chapter 1: "Introduction", sections 1 through 6
  • Discussion 4.
  • Lab 3 due

 

 

Oct 21/22: Lab 4

Nonlinear Systems Analysis

5

Oct 26, lecture 8 System Identification I ( Parameter estimation, least squares, The importance of measurement error and weighting schemes)

  • Recommended: Khoo, Chapter 7.1, 7.2.1 and 7.2.2
  • no written article discussion due. Instead:
  • Project 1 proposal due at 10:00 am via (project plan).
Oct 28, lecture 9 System Identification II (Examples)
  • Lab 4 due.
  • Discussion 5

Oct 28/29 lab 5

System Identification

data file for lab 5

6

<-- RETURN TO TOP

Nov 2, lecture 10. Stochastic Simulations Overview (Review of probability distributions and statistics, definition of stochastic processes, examples)

Nov 4, lecture 11. Brownian Dynamics (Diffusion; Langevan Equation, Wiener Process)

Nov 4/5 Lab 6

Diffusive Stochastic Processes

7

Nov 9, lecture 12. Stochastic chemical reaction equations (Gillespie Exact, Tau-leap method, Chemical Langevin Equation)

  • no reading or discussion assignment
  • Project 1 delayed until Nov 12

Nov 11, lecture 13

Veteran's Day - no lecture, no lab

 

  • finish project 1!

 

Nov 12

  • Project 1 due 10:00 am to collectit
8

Nov 16, lecture 14. Stochastic Chemical Reactions examples (Deepak Chandran)

  • stochastic chemical reactions: examples
  • discuss project ideas.
  • project 2 posted

 

 

Nov 18, lecture 15 Stochastic Chemical Reactions (Deepak Chandran)

  • stochastic chemical reactions: examples
  • discuss project ideas.
  • Lab 6 due 10:00 am

Nov 19/20 Lab 7 Stochastic chemical reaction equations

 

9

<-- RETURN TO TOP

Nov 23, lecture 16 class cancelled due to snow

  • project 2 proposal due 10 am

No lecture -

  • Thanksgiving Holiday
  • spend this week working on project 2!

No lab -

  • Happy Thanksgiving!
10

Nov 30 , lecture 17 Introduction to Partial Differential Equations (old ppt overview and new handwritten intro notes).

  • project 2 impact discussion due 10 am

Dec 2, lecture 18 analytic and numerical solutions methods

  • lab 7 due

 

Dec 3/4

  • lab 8 PDEs
11

Dec 7, lecture 19. Nondimensionalization for PDE and ODE models (helps identify fundamental behaviors of model)

  • project 2 validation discussion due 10 am
  • posted: digitize data m-file, which can be used to pluck numerical data from a digital figure.

Dec 9, lecture 20: Review and Course Evaluations.

  • lab 8 due

Dec 11/12. Model demonstrations in lab

finals week

Tuesday, Dec 14

  • project 2 due at 5:00 pm

Wednesday, Dec 15 4:30-6:20 MGH 271.

happy winter break!

 

 

<-- RETURN TO TOP

 Last Updated:
December 17, 2010