Biostat 580B - Statistical Genetics Seminar

Instructor: Ellen Wijsman
Instructor: Elizabeth Thompson

1 credit

Winter Quarter 2002
Seminar: Tuesday 4:00-5:00, in F643 HSB (biostatistics conference room)

Link to Spring Quarter 2002 Page

Reminder: Everyone should read the papers for weeks in which we read a journal article. If the paper is available electronically, we will simply provide the reference, and everyone should download their own copies. If the paper is not available electronically, the discussion leaders should make 2 copies, and should put one copy in each of the stat mailbox and the biostat 580B homework folder, preferably a week ahead of time. The stat mailbox is in the mail room in statistics; the biostat homework folder is in the top left drawer underneath the biostat mailboxes in a folder to the far left as you face the mailboxes. Everybody else should make a copy from the copy left in the stat mailbox, or the purple biostat 580B homework folder under the biostat mailboxes. (If the paper is available electronically, copies can be made from the electronic links.) Discussion leaders are only expected to spend 20-30 minutes (jointly) presenting the assigned paper(s). If you don't understand everything, focus on what you can, and try to think about what is important about the papers, and what open questions you are left with. MAKE SURE YOU LEAVE ADEQUATE TIME FOR DISCUSSION.

Remember the important questions:

Why? What? Why? How? Why? What next? and WHY?

(Why is this question important? What did they do? Why did they choose this approach? How did they do it? Why did they choose these methods? What should come next? Why is this paper important? )

For a link to the list of suggested topics collected Oct. 2, 2001, click here. It appears that a good pair of "themes" for the fall is (1) haplotype/disequlibrium issues, and (2) complex trait gene mapping.

For a link to the list of suggested topics collected Sept. 26, 2000 click here.

For a list of papers considered in Spring 2001 click here.

Many articles can be obtained electronically. Journals with electronic issues can be accessed through the healthlinks web site, or through the UW e-journals page.

Winter 2002 SCHEDULE

Jan. 8: Ellen Wijsman will talk, if nobody else is ready.

Topic: complex trait mapping in human pedigrees.

Jan. 15: Dongmei Yu, Zheng Zhang

J. K. Pritchard and M. Przeworski
Linkage Disequilibrium in Humans: Models and Data,
Am. J. Hum. Genet. 69: 1-14, 2001

Jan. 22: CANCELLED

Jan. 29: Saonli Basu, Lance Jolley

Forrest W. and Feingold E. (2000)
Composite Statistics for QTL Mapping with Moderately Discordant Sibling Pairs
Am. J. Hum. Genet. 66 : 1642-1660.

Feb. 5: Amy Anderson, Lixuan Qin

Lei Sun, Nancy J. Cox, and Mary Sara McPeek (2002)
A Statistical Method for Identification of Polymorphisms That Explain a Linkage Result.
Am. J. Hum. Genet. 70: 399-411

Feb. 12: Michael Li:

Will talk on his own research topic of "Estimating local recombination rate from population haplotype data".

Feb. 19: Kyriacos Markianos, Angel Wan will present:

Zeng ZB. Precision mapping of quantitative trait loci. Genetics 1994 Apr;136(4):1457-68

Lander ES, Botstein D., Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 1989 Jan;121(1):185-99

Note: these papers are in the statgen box, since they predate online access.

Feb. 25: Solly Sieberts, Xuesong Yu

Sobel et al. (2002) Detection and integration of genotyping errors in statistical genetics. Am J Hum Genet 70:496-508.

Mar. 5: Bill Stewart, Joe Rothstein

Lange K. and Matthysse S, (1989) "Simulation of Pedigree Genotypes by Random Walks." AJHG, 1989 Dec;45(6):959-70

Mar. 12: Peter Mork, Elisabeth Rosenthal

Cordell H and Clayton D (2002) Stepwise Procedure for Polymorphisms within a Gene. Am J Hum Genet 70:124-141

For a link to other seminars of related interest, click here.

Previous Quarters

1997: Winter, Spring, Fall
1998: Winter, Spring, Fall
1999: Winter, Spring , Fall
2000: Winter, Spring, Fall
2001: Winter, Spring, Fall

Return to Biostat Homepage
These pages are Copyright © 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2002 by University of Washington, including all images and photographs (of more than 20,000 pixels in size) unless otherwise noted.