Biostat 580B - Statistical Genetics Seminar
1 credit
Fall Quarter 2002
Seminar: Tuesday 4:00-5:00, in F643 HSB
(biostatistics conference room) Note that location is NOT what is
listed in the time schedule!!
Remember the important questions:
Why? What? Why? How? Why? What next? and WHY?
(Why is this question important? What did they do? Why did they choose this approach?
How did they do it? Why did they choose these methods? What should
come next? Why is this paper important? )
Reminder: Everyone should read the papers for weeks in which we read a journal article.
If the paper is available electronically, we will provide the reference, and
you may download your own copy from
the
healthlinks web site,
or through the
UW e-journals page.
If the paper is not available electronically,
the discussion leaders should make 2 copies, and should put one copy in each of the
stat mailbox and the biostat 580B homework folder, preferably a week ahead of time.
The stat mailbox is in the mail room in statistics;
the biostat 580B homework folder is
in the top left drawer underneath the biostat mailboxes in a folder to the far left
as you face the mailboxes.
Others should then make their copies from one of these two copies.
Discussion leaders are only expected to spend 20-30 minutes (jointly)
presenting the assigned paper(s). If you don't understand everything, focus on
what you can, and try to think about what is important about the papers, and
what open questions you are left with.
MAKE SURE YOU LEAVE ADEQUATE TIME FOR
DISCUSSION.
Statistical Genetics Computing in Biostat
Statistical Genetics at UW has
software installed for the use of UW StatGen students and others.
This software is installed and maintained at
our Statgen Biostatistics computing page. To use the software,
a biostat computing account is needed:
Biostat 580B seminar participants may obtain an account through this class.
(Since this is an ongoing class, with ongoing participation by StatGen people
(we hope!), we believe this will lead to less admin headaches for all.)
Please note: Your Biostat computing account given
in connection with
the Statistical Genetics seminar is for learning and exploring the software,
not
for doing your research computing. Your research computing should be done
on computing resources allocated for that purpose.
Winter 2003 SCHEDULE
Jan. 7:
We will use this first session of the quarter to organize the quarter.
I just haven't had time to do it over "break". NOTE: we decided on haplotype
blocks for ~ 4 weeks, and the complex traits. Everyone was assigned one
journal to search for haplotype block-related papers for publication year 2002.
Jan. 14: Ellen Wijsman
Genetic analysis of complex traits.
Jan. 21: Michael Li & Jackie Starr
The next 4 weeks will involve the following papers, in the order below
(we may not get to all of them). Michaell will begin by summarizing part of
the DIMACS/RECOMB Satellite workshop on COmputations Methods for SNPs and
Haplotype Inference. Jackie will continue with the Kang et al paper.
- Kang et al (2002) Haplotype block structure and its applications to
association studies; power and study designs. American Journal of Human
Genetics 71:1386-1394.
- Gabriel et al (2002) The structure of haplotype blocks in the human
genome. Science 296:2225-2229.
- Wang et al (2002) Distribution of recombination crossovers and the origin
of haplotype blocks: the interplay of population history, recombination,
and mutation. American Journal of Human Genetics 71:1227-1234.
- Zhang et al (2002) A dynamic programming algorithm for haplotype block
partitioning. Proceedings of the National Academy of Sciences, USA
99:7335-7339.
Jan. 28: Grace Ge/Ting-Yuan Liu
We will pick up where we stopped on Jan 21.
Feb. 4: Dongmei Yu/Rob Igo
We will pick up where we stopped on Jan 28.
Feb. 11: Solly Sieberts (research talk) - note change in schedule!
Feb. 18: Amy Anderson
We will pick up where we stopped on Feb 4.
Feb. 25: Joe Rothstein
We switch to MCMC in the context of complex genetic traits.
Hastings WK (1970) Monte Carlo sampling methods using Markov
chains and their applications. Biometrika 57(1):97-109.
a copy is in the biostat folder, and there is a link:
here
Mar. 4: Angel (Jian Tin) Wan
Guo SW and Thompson EA (1992) A Monte Carlo method for combined segregation
and linkage analysis. Am J Hum Genet 51:1111-1126.
copy of paper in biostat folder
Mar. 11: Elisabeth Rosenthal
Heath SC (1997) Markov chain Monte Carlo segregation and linkage analysis
for oligogenic models. Am J Hum Genet 61:748-760.
For a link to other seminars of related interest,
click here.
Previous Quarters
1997:
Winter,
Spring,
Fall
1998:
Winter,
Spring,
Fall
1999:
Winter,
Spring ,
Fall
2000:
Winter,
Spring,
Fall
2001:
Winter,
Spring,
Fall
2002:
Winter
Spring
Fall
http://courses.washington.edu/b580b
Last updated:
Tuesday, 18-Mar-2003 14:03:54 PST
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